1. Guo C, Peng Y, Lin L, Pan X, Fang M, Zhao Y, Bao K, Li R, Han J, Chen J, Song TZ, Feng XL, Zhou Y, Zhao G, Zhang L, Zheng Y, Zhu P, Hang H, Zhang L, Hua Z*, Deng H*,Hou B*. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates.Cell Rep Med. 2021 Nov 16;2(11):100448. doi: 10.1016/j.xcrm.2021.100448. Epub 2021 Oct 23. PMID: 34723223; PMCID: PMC8536523.

2. Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, Iwakura Y, Meng G, Hua Z, Yan B, Liu WJ, Luo Z, Gong S, Chen H, Li S*,Hou B*, Tang H*. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin.Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2019798118. doi: 10.1073/pnas.2019798118. PMID: 33875594; PMCID: PMC8092388.

3. Hua Z*,Hou B*. The role of B cell antigen presentation in the initiation of CD4+ T cell response.Immunol Rev. 2020 Apr 18. doi: 10.1111/imr.12859. [Epub ahead of print] Review. PMID:32304104

4. Hong S, Zhang Zhimin, Liu H, Tian M, Zhu X, Zhang Zhuqiang, Wang W, Zhu B, Zhou X, Zhang F, Ge Q, Tang H*, Hua Z*,Hou B*.B cells are the dominant antigen-presenting cells that activate naive CD4+ T cells upon immunization with a virus-derived nanoparticle antigen.Immunity, 2018, Sep 21. pii: S1074-7613(18)30353-4. doi: 10.1016/j.immuni.2018.08.012. [Epub ahead of print]

  ◆Selected and recommended by Faculty of 1000

5. Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL andHou B*.B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle.J Immunol. 2018 February 1. 200 (3) 937-948. PMID: 29282308

6. Liao W, Hua Z, Liu C, Lin L, Chen R,Hou B*.Characterization of T-Dependent and T-Independent B Cell Responses to a Virus-like Particle.J Immunol. 2017 May 15. PMID:28416599

7. Anas AA, Yang J, Daan de Boer J, Roelofs JJ,Hou B, de Vos AF, van der Poll T. General, but not myeloid or type II lung epithelial cell, myeloid differentiation factor 88 deficiency abrogates house dust mite induced allergic lung inflammation.Clin Exp Immunol. 2016 Sep 14. PMID: 27625307

8. Anas AA, van Lieshout MH, Claushuis TA, de Vos AF, Florquin S, de Boer OJ,Hou B, Van't Veer C, van der Poll T. Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism.Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L219-28. PMID: 27288486

9. de Stoppelaar SF, Claushuis TA, Schaap MC,Hou B, van der Poll T, Nieuwland R, van 't Veer C. Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo.PLoS One. 2016 Jun 2;11(6):e0156977. PMID: 27253707

10. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS,Hou B, Buckner JH, Rawlings DJ. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.J Exp Med. 2016 May 2;213(5):733-50. PMID: 27069113

11. de Stoppelaar SF, Claushuis TA, Jansen MP, Hou B, Roelofs JJ, van 't Veer C, van der Poll T. The role of platelet MyD88 in host response during gram-negative sepsis.J Thromb Haemost.2015 Sep;13(9):1709-20. PMID: 26178922.

12. van Lieshout MH, Anas AA, Florquin S,Hou B, Van't Veer C, de Vos AF, van der Poll T. Hematopoietic but Not Endothelial Cell MyD88 Contributes to Host Defense during Gram-negative Pneumonia Derived Sepsis.PLoS Pathog. 2014 Sep 25;10(9):e1004368. PMID: 25254554

13. Fan X, Wang X, Li N, Cui H,Hou B, Gao B, Cleary PP, Wang B. Sortase a induces Th17-mediated and antibody-independent immunity to heterologous serotypes of group a streptococci.PLoS One. 2014 Sep 18;9(9):e107638. PMID: 25232948

14. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA,Hou B*,DeFranco AL*. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.J Immunol.2014 Feb 1;192(3):875-85. PMID: 24379120

15. Hua Z,Hou B*.TLR signaling in B cell development and activation.Cell. Mol. Immunol.,Vol.10, 103-106, 2013. PMID: 23241902

16. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S,Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells.Nat Immunol.2013 Feb;14(2):136-42. PMID: 23263554

17. Wu H, Tao N, Liu X, Li X, Tang J, Ma C, Xu X, Shao H,Hou B*,Wang H*, Qin Z*. Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells.PLoS One.2012;7(12):e51751. PMID: 23272159.

18. Kim CC, Nelson CS, Wilson EB,Hou B, Defranco AL, Derisi JL.Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control.PLoS One.2012;7(10):e48126. PMID: 23144737.

19. DeFranco AL, Rookhuizen D,Hou B. Contribution of TLR signaling to germinal center antibody responses.Immunological reviews.2012 May;247(1):64-72. PMID: 22500832.

20. Thompson AL, Johnson BT, Sempowski GD, Gunn MD,Hou B, Defranco AL, Staats HF. Maximal Adjuvant Activity of Nasally Delivered IL-1α Requires Adjuvant-Responsive CD11c+ Cells and Does Not Correlate with Adjuvant-Induced In Vivo Cytokine Production.J Immunol.2012 Mar 15;188(6):2834-46. PMID: 22345651.

21. Kirkland D, Benson A, Mirpuri J, Pifer R,Hou B, Defranco AL, Yarovinsky F. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage.Immunity.2012 Feb 24;36(2):228-38. PMID: 22306056.

22. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ,Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.Nat Immunol. 2011 Oct 23;12(12):1184-93. PMID: 22019834.

23. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA,Hou B, DeFranco AL, Yarovinsky F, Hooper LV. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface.Proc Natl Acad Sci USA. 2011 May 24;108(21):8743-8. PMID: 21555560.

24.Hou B*,Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee L, Coffman R, Bachmann M, DeFranco AL*. Selective utilization of TLR/MyD88 signaling in B cells for enhancement of the anti-viral germinal center response.Immunity2011 Mar 25;34(3):375-84. PMID: 21353603.

◆Selected and recommended by Faculty of 1000

25. Rahman AH, Zhang R, Blosser CD,Hou B, DeFranco AL, Maltzman JS, Wherry EJ, and Turka LA. Anti-viral memory CD8 T cell differentiation, maintenance and secondary expansion occur independent of MyD88.Blood2011 Mar 17;117(11):3123-30. PMID: 21233312.

26.Hou B*,Benson A, Kuzmich L, DeFranco AL, Yarovinsky F*. Critical coordination of innate immune defense to Toxoplasma gondii by dendritic cells responding via their Toll-like receptors.Proc Natl Acad Sci USA.2011 Jan 4;108(1):278-83. PMID: 21173242.

27.Hou B, Reizis B, DeFranco AL. Toll-like receptor-mediated dendritic cell-dependent and –independent stimulation of innate and adaptive immunity.Immunity2008 Aug; 29(2): 272-82. PMID: 18656388.

◆Highlighted in News View. Immunity 2008

◆Selected and evaluated for the Faculty of 1000

28. Mamchak AA, Sullivan BM,Hou B, Lee LM, Gilden JK, Krummel MF, Locksley LM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.J Immunol. 2008 Oct 15; 181(8): 5374-85)

29.Hou B, Eren M, Covington JW, Painter CA, Dixon JD, Schoenhard JA, Vaughan DE. Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kB site.J of Biol. Chem.2004; 279(18): 18127-18136. PMID: 14963043.

30.Hou B, Pan J, Fan L, Gao J. Analysis of the clinical and laboratory patterns of DIC with different primary etiology and evaluation of heparin therapy.National Medical Journal of China2001; 81(2): 752-753

31.Hou B, Liu D. Application and significance of APACHE II (Acute Physiology and Chronic Health Evaluation II) score system in the treatment of critically ill patients.Chinese Critical Care Medicine1997; 9: 735-738

32. Du B, Zhang, H, Chen D, Liu D,Hou B, Xiong W, Liu T, Chen J. Invasive fungal infection in 3447 autopsy cases.National Medicine Journal of China1996; 76:352-354