iPSC technology to study human aging and aging-related disorders.Curr Opin Cell Biol. 2012 Sep 18. pii: S0955-0674(12)00139-1. doi: 10.1016/j.ceb.2012.08.014.

Current Opinion in Cell Biology 2012 Sep 18. pii: S0955-0674(12)00139-1. doi: 10.1016/j.ceb.2012.08.014.

iPSC technology to study human aging and aging-related disorders.

Liu GH, Ding Z, Izpisua Belmonte JC

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: ghliu@ibp.ac.cn.

Abstract

A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.

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