中文 Prof. Yan Qin Group Research  

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A complete list of publications can be found HERE

Zhang D, Kaige Y, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Lou Z, Gao N* and Qin Y* (2016) (*corresponding author) EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome, Nat Struct Mol Biol.
Abstract    Full Text Link    Full Text PDF

Zhang Y, Mandava CS, Cao W, Li X, Zhang D, Li N, Zhang Y, Zhang X, Qin Y, Mi K, Lei J*, Sanyal S*, Gao N* (2015) (*corresponding author) HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions, Nat Struct Mol Biol. 22, 906–913.
Abstract    Full Text Link    Full Text PDF

Zhang D, Kaige Y, Zhang Y, Liu G, Cao X, Song G, Xie Q*, Gao N*, Qin Y* (2015) (*corresponding author) New insights into the enzymatic role of EF-G in ribosome recycling,Nucleic Acids Res.1674–1683.
Abstract    Full Text Link    Full Text PDF

Liu G, Zhang D, Song G, Li Z, Zhang D, Lyv Z, Aachenbach J, Dong J, Gong W, Zhao X, Nierhaus K H and Qin Y* (2014) (*corresponding author) EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex, Nat Struct Mol Biol. 21, 817–824.
Abstract    Full Text Link    Full Text PDF

Yang F, Gao Y, Li ZK, Chen LM, Xia Z, Xu T*, Qin Y* (2014) (*corresponding author) Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans. Biochim Biophys Acta. 1674–1683.
Abstract    Full Text Link    Full Text PDF

Yamamoto H#, Qin Y#, Achenhach J#, Li X, Kijek J, Kijek J, Sphan CMT and Nierhaus HK (2014) (#co-first author) EF-G and EF4: Translocation and back-translocation on the bacterial ribosome. Nat Rev Microbiol. 12 (2) 89-100 (Invited review).
Abstract   Full Text Link    Full Text PDF

Zhang D and Qin Y* (2013) (*corresponding author) The Paradox of Elongation Factor 4: highly conserved yet of no physiological significance? Biochem J. 452 (2), 173-181 (invited review).
Abstract   Full Text Link    Full Text PDF

Zhang D, Liu G, Xue J, Lou J, Nierhaus K H, Gong W* and Qin Y* (2012) (*corresponding author) Common chaperone activity in the G-domain of trGTPase protects L11–L12 interaction on the ribosome, Nucleic Acids Res. 40 (21) 10851-10865.
Abstract    Full Text Link    Full Text PDF

Wang L, Yang F, Zhang D, Chen Z, Xu R, Nierhaus K H, Gong W and Qin Y* (2012) (*corresponding author) A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases, Nat Struct Mol Biol.19(4)403-410.
Abstract    Full Text Link    Full Text PDF

Di Giacco V#, Marquez V#, Qin Y#, Pech M, Triana-Alonso FJ, Wilson DN, Nierhaus KH (2008) (#co-first author). Shine-dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the aug. Proc Natl Acad Sci U S A. 105(31):10715-10720.
Abstract    Full Text Link    Full Text PDF

Connell SR#, Topf M#, Qin Y#, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM (2008) (#co-first author) A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nat Struct Mol Biol. 15(9):910-915.
Abstract   Full Text Link    Full Text PDF

Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH* (2006) (*corresponding author) The highly conserved lepa is a ribosomal elongation factor that back-translocates the ribosome. Cell. 127(4):721-733.
Abstract   Full Text Link    Full Text PDF