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中科院青促会会员

冯菡  博士 副研究员  

中国科学院青年创新促进会会员

研究方向:病原菌感染及宿主免疫应答

电子邮件:qingfengpa@163.com

电       话:010-64887122

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582885.json

 

简       历:

  2006.09 - 2011.06  吉林大学,学士

  2011.09 - 2016.06  中国科学院生物物理研究所,博士

  2016.07 - 2019.12  中国科学院生物物理研究所,助理研究员

  2020.01 - 至今        中国科学院生物物理研究所,副研究员

获奖及荣誉:

 

社会任职:

 

研究方向:

  利用结构生物学手段(X-ray 和冷冻电镜)并结合生物化学及细胞生物学等手段,探索感染与免疫相关的生物学问题,包括病原体感染及宿主免疫应答两个方面。

承担项目情况:

 

代表论著:

  1. Feng Han#, Tian Huabin#, Wang Yong, Zhang Qixiang, Lin Ni, Liu Songqing, Yu Yang, Deng Hongyu*, GaoPu*. Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10. PNAS, 2020.10.27 117 (43) 26719-26727

  2. Zhu Yalan#; Gao Ang#; Zhan Yi; Wang Yong; Feng Han; Liu Songqing; A. Serganov* and Gao Pu*. Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Molecular cell,2019.4.18 74(2): 296~309.

  3. Wang Yong#; Shi Miao; Feng Han; Zhu Yalan; Liu Songqing; Gao Ang*; Gao Pu*. Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 2018.5.17 173(5): 1231~1243.

  4. Feng Han#; Liu Xuehui; Wang Sheng; Fleming Joy; Wang Da-Cheng*; LiuWei*. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nature Communications, 2017.12.21 8(2242).

  5. Feng Han#; Ding Jingjin#; Zhu Deyu#; Liu Xuehui; Xu Xueyong; Zhang Ying; Zang Shanshan; Wang Da-Cheng*; Liu Wei*. Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. Journal of the American Chemical Society, 2014.10.22 136(42): 14694~14697.

  6. Wang Yong#; Feng Han#; Zhu Yalan; Gao Pu(*).Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes. Protein & Cell, 2017.03.07 8: 308~312.

  7. Feng Han#; Wang Sheng#; Guo Ling; Punekar Avinash S.; Ladenstein Rudolf; Wang Da-Cheng*; Liu Wei*. MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction. Protein & Cell, 2016.12 7(12) : 916~920.

  8. Feng Han#; Liu Wei; Wang Da-Cheng*. Purification crystallization and X-ray diffraction analysis of the DNA-binding domain of human heat-shock factor 2. Acta Crystallographica Section F-Structural Biology Communications, 2016.4 72 : 294~299.

 

(资料来源:冯涵副研究员,2020-10-29)