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中科院青促会会员

王曦  博士 副研究员  

中国科学院青年创新促进会会员
中科院生物物理所,生物大分子国家重点实验室

研究方向:内质网蛋白质氧化折叠

电子邮件:wangxi@ibp.ac.cn

电       话:010-64888501

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582906.json

 

简       历:

  1999.09 - 2003.06  武汉大学生命科学学院,生物学基地班,理学学士

  2003.09 - 2008.06  中国科学院生物物理研究所,理学博士

  2008.07 - 2011.12  中国科学院生物物理研究所,助理研究员

  2012.01 - 至今       中国科学院生物物理研究所,副研究员

  2015.12 - 2016.11  The Scripps Research Institute,访问学者

获奖及荣誉:

 

社会任职:

 

研究方向:

  二硫键对很多分泌蛋白和膜蛋白结构的稳定、功能调节有重要贡献,而二硫键形成是蛋白质氧化折叠重要的限速步骤之一。我们对蛋白质氧化折叠系统中的关键酶开展结构功能关系及分子机制研究。近期利用细胞生物学、生物化学和结构生物学多学科交叉研究细胞内蛋白质稳态调节及其对人类健康的影响。

承担项目情况:

  1. 国家自然科学基金面上项目,“氧化还原酶调节内质网氧化还原稳态的机制”,2019-2022,负责人

  2. 国家自然科学基金面上项目,“Peroxiredoxin 4介导蛋白质氧化折叠通路分子机制及结构基础”,2014-2017,负责人

  3. 国家自然科学基金青年科学基金,“人源QSOX1在蛋白质氧化折叠和质量控制中的作用”,2010.01– 2012.12,负责人

代表论著:

  1. Jiaojiao Yu, Tao Li, Yu Liu, Xi Wang, Jianchao Zhang, Xi'e Wang, Guizhi Shi, Jizhou Lou, Likun Wang, Chih-chen Wang, Lei Wang (2020) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J 39: e103841

  2. Shili Xu, Yajing Liu, Kai Yang, Hanxiao Wang, Andrea Shergalis, Anahita Kyani, Armand Bankhead III, Shuzo Tamura, Suhui Yang, Xi Wang, Chih-chen Wang, Alnawaz Rehemtulla, Mats Ljungman, Nouri Neamati (2019) Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes. Theranostics 9:2282-2298.

  3. Yini Zhang, Tao Li, Lihui Zhang, Fugen Shangguan, Guizhi Shi, Xun Wu, Ya Cui, Xi'e Wang, Xi Wang, Yongzhang Liu, Bin Lu, Taotao Wei, Chih-chen Wang, Lei Wang (2019) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBioMedicine 41:408-419.

  4. Jianchao Zhang, Qinyu Zhu, Xi'e Wang, Jiaojiao Yu, Xinxin Chen, Jifeng Wang, Xi Wang, Junyu Xiao, Chih-chen Wang, Lei Wang (2018) Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α. EMBO J., 37:e98699.  

  5. Kai Yang, De-Feng Li, Xi’e Wang, Jinzhao Liang, Roberto Sitia, Chih-chen Wang#, Xi Wang# (2016) Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention. Structure, 24:1755-1765. (#co-corresponding author)

  6. Lei Wang*, Xi Wang*, Chih-chen Wang (2015) Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. Free Radic Biol Med, 83:305-13. (*co-first author)

  7. Li Zhu, Kai Yang, Xi’e Wang, Xi Wang# and Chih-chen Wang# (2014) A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. PLoS One, 9:e105529. (#co-corresponding author)

  8. Shang Yang*, Xi Wang*, Lei Cui, Xiang Ding, Lili Niu, Fuquan Yang, Chao Wang, Chih-chen Wang, Jizhong Lou (2014) Compact conformations of human protein disulfide isomerase. PLoS One, 9:e103472. (*co-first author)

  9. Xi Wang*, Likun Wang*, Xi’e Wang, Fei Sun and Chih-chen Wang (2012) Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. Biochem J., 441:113–118. (*co-first author)

  10. Chao Wang, Sihong Chen, Xi Wang, Lei Wang, A. Katrine Wallis, Robert B. Freedman and Chih-chen Wang (2010) Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance. J Biol Chem., 285: 26788-97.

  11. Guoping Ren*, Xi Wang*, Shufeng Hao, Hongyu Hu and Chih-chen Wang (2007) Translocation of alpha-synuclein expressed in Escherichia coli. J Bacteriol., 189: 2777-86. (*co-first author)

 

(资料来源:王曦副研究员,2020-12-07)