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中科院青促会会员

朱玲  博士 副研究员  

中国科学院青年创新促进会会员 
中科院生物物理所,中国科学院感染与免疫重点实验室

研究方向:病毒结构生物学

电子邮件:lingzhu@ibp.ac.cn

电       话:010-64888554

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582891.json

 

简       历:

  2005 - 2009  四川大学生命科学学院,理学学士p>

  2009 - 2012  四川大学华西医院生物治疗国家重点实验室,医科硕士

  2013 - 2017  牛津大学医学科学院,理学博士

  2018 - 至今  中国科学院生物物理研究所,副研究员

获奖及荣誉:

 

社会任职:

 

研究方向:

  小RNA病毒家族是一类无包膜、由正二十面体衣壳蛋白包裹着单股正链RNA病毒,家族成员可导致人手足口病、甲型肝炎、脊髓灰质炎等多种疾病。使用结构生物学、细胞生物学等技术手段,揭示小RNA病毒入侵宿主细胞、病毒脱衣壳的分子机制,设计抑制病毒入侵的小分子药物;筛选稳定性好和免疫原性佳的候选疫苗。

承担项目情况:

  1. 国家自然科学基金委青年基金,小RNA病毒科C亚科重要病原体2A蛋白的结构与功能研究,2019-2021,主持

  2. 国家重点研发计划非公开项目课题,2018-2021,主持

  3. 中国科学院战略性先导专项,病原体宿主适应与免疫干预,2018-2023,参与

代表论著:

  1. Zhu L#*, Sun Y#, Fan J#, Zhu B, Cao L, Gao Q, Zhang Y, Liu H, Rao Z*, Wang X*. Structures of CoxsackievirusA10 shed light on the molecular mechanisms of receptor binding and uncoating of enteroviruses. Nature Communications, 2018 , 2018, 9: 4985. 

  2. Zhu L#, Xu K#, Wang N#, Cao L, Wu J, Gao Q, Fry E.E, Stuart D.I, Rao Z, Wang J, Wang X*. Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71. Mbio. 2018, 01013-18.

  3. Zhu L#, Wang X#, Ren J, Kotecha A, Walter T.S, Yuan S, TuthillT.J, Fry E.E, Rao Z* and Stuart D.I*. Structure of human Aichi virus and implications for receptor binding. Nature Microbiology. 2016.9.5, 1 (11):16150~16150   

  4. Zhu L#, Wang X#, Ren J, Porta C, Wenham H, Ekstrom J, Panjwani A, Knowles N.J, Kotecha A, Siebert A.C, A. Lindberg M, Fry E.E, Rao Z and Stuart D.I. Structure of Ljungan virus reveals a novel mechanism for picornavirus genome packaging. Nature Communications. 2015,6:8316. 

  5. Zhu L, Zhang X. Hepatitis A virus exhibits a structure unique among picornaviruses, Protein & Cell. 2015, 6(2):79–80. 

  6. Wang X#*, Zhu L#, Dang M#, Hu Z#, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Wang J, Fry E.E*, Stuart D.I* and Rao Z*. Potent neutralization of Hepatitis A virus reveals effected by a receptor mimic mechanism. Proc Natl Acad Sci U S A, 2017.1.24, 114(4):770~775. 

  7. Wang X#, Li S#, Zhu L#, Nian Q#, Gao Q, Nian Q, Hu Z, Fry E.E, Qin C*, Stuart D.I* and Rao Z*. Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability, Nature Communications, 2017, 10.1038. 

  8. Ren J#, Wang X#, Zhu L#,Hu Z#, Li X, Wang J, Fry E.E, Rao Z* and Stuart D.I*. Structures of coxsackievirusA16 capsids with native antigenicity, implications for particle expansion, receptor binding and immunogenicity. Journal of Virology. 2015. 89 (20) :10500-10511. 

  9. Xie D, Liu Z, Nian Q, Zhu L, Wang N, Deng Y, Zhao H, Ji X, Li X, Wang X, Shi P & Qin C. A single residue in the αB helix of the E protein is critical for Zika virus thermostability. Emerging Microbes &Infections , 2018.10.1038/s41426-017-0006-9. 

 

(资料来源:朱玲副研究员,2020-10-27)