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中科院青促会会员

马军  博士 副研究员  

中国科学院青年创新促进会会员 
中科院生物物理所,生物大分子国家重点实验室

研究方向:病毒与宿主相互作用

电子邮件:majun@ibp.ac.cn

电       话:010-64887082

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_zkyqchhy/202005/t20200519_5582889.json

 

简       历:

  2003 - 2007  兰州大学生命科学学院,理学学士

  2008 - 2014  中国科学院生物物理研究所,理学博士

  2015 - 2017  中国科学院生物物理研究所,博士后

  2017 - 至今  中国科学院生物物理研究所,副研究员

获奖及荣誉:

 

社会任职:

 

研究方向:

  以冷冻电镜结构生物学为主要研究手段,研究与人类疾病密切相关的病毒所编码的蛋白质及其与宿主蛋白质相互作用的生理功能与结构基础,以期阐明病毒感染与致病的分子机理并为抗病毒治疗策略提供有用的信息。

承担项目情况:

  1. 国家自然科学基金青年科学基金项目:COPs蛋白质负调节炎症小体活性的结构与功能研究,2017-2019,主持

  2. 国家自然科学基金面上项目:NLRP3炎症小体相关蛋白质复合物的结构及功能机制的冷冻电子显微学研究,2016-2019,参与

代表论著:

  1. You L#, Ma J#, Wang J#, ArtamonovaD, Wang M,Liu L, Xiang H, Severinov K, Zhang X* andWang Y*. Structure studies of the CRISPR-Csm complex reveal mechanism of co-transcriptional interference. Cell, 2019, 176(1-2):239-253. 

  2. Su X#, Ma J#, Pan X#, Zhao X, Chang W, Liu Z, Zhang X*, Li M*. Antenna arrangement and energy transfer pathways of a green algal photosystem I-LHCI supercomplex. Nature Plants, 2019, 5(3):273-281.

  3. Ma J, Zhai Y, Chen M, Zhang K, Chen Q, Pang X*, Sun F*. New interfaces on MiD51 for Drp1 recruitment and regulation. PLoS One, 2019, 14(1):e0211459.   

  4. Pan X#, Ma J#, Su X#, Cao P, Chang W, Liu Z, Zhang X*, Li M*. Structure of the maize photosystem I supercomplex with light harvesting complexes I and II. Science, 2018, 360(6393):1109-1113. 

  5. Chen L#, Wang M#, Zhu D#, Sun Z#, Ma J, Wang J, Kong L, Wang S, Liu Z, Wei L, He Y, Wang J*, Zhang X*. Implication for alphavirus host-cell entry and assembly indicated by a 3.5? resolution cryo-EM structure. Nature Communications, 2018, 9(1):5326. 

  6. David L, Li Y, Ma J, Garner E, Zhang X, Wu H. Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proc Natl Acad Sci U S A, 2018, 115(7):1499-1504.

  7. Su X#, Ma J#, Wei X#, Cao P,# Zhu D, Chang W, Liu Z*, Zhang X*, Li M*. Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex. Science, 2017, 357(6353):815-820. 

  8. Liu L#, Li X#, Ma J#, Li Z#, You L, Wang J, Wang M, Zhang X*, Wang Y*. The molecular architecture for RNA-guided RNA cleavage by Cas13a. Cell, 2017, 170(4):714-726.

  9. Yuan Y#, Cao D#, Zhang Y#, Ma J#, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y*, Zhang X*, Gao GF*. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains. Nature Communications, 2017, 8:15092.    

  10. Wang J#, Ma J#, Cheng Z, Meng X, You L, Wang M, Zhang X*, Wang Y*.A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses.Cell Research, 2016, 26(10):1165-1168. 

  11. Ma J, Sun F. Expression, purification, crystallization and preliminary crystallographic study of the cytoplasmic domain of the mitochondrial dynamics protein MiD51. Acta Crystallographica Section F, 2014, F70: 596-599. 

  12. Pang X, Fan J, Zhang Y, Zhang K, Gao B, Ma J, Li J, Deng Y. Zhou Q, Egelman E.H, Hsu VW and Sun F. A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature. Developmental Cell, 2014, 31(1):73-86.

  13. Wang X, Xu F, Liu J, Gao B, Liu Y, Zhai Y, Ma J, Zhang K, Baker T.S, Schulten K, Zheng D, Pang H & Sun F. Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography. PLoS Pathogens, 2013, 9(1): e1003132.

  14. Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic insights into regulated cargo binding by ACAP1. Journal of Biological Chemistry, 2012, 287: 28675-28685.

 

(资料来源:马军副研究员,2020-10-28)