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优秀青年科学基金获得者

秦燕  博士 研究员 博士生导师  

"干细胞及转化"国家重点研发计划首席科学家(2018-2022)
中青年科技创新领军人才
中科院生物大分子科教融合卓越中心骨干人才,RNA平台首席技术专家
中国科学院大学,岗位教授

研究方向:(1)干细胞与核糖体:蛋白质在核糖体上的生物合成过程的机理,及其调控干细胞命运的生理、病理过程;(2)癌症与核糖体:癌症发生、恶化、转移过程中的疾病模型、诊断、治疗

电子邮件:qiny@ibp.ac.cn

电       话:010-64888434

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_xsszmQ_V/202005/t20200519_5582985.json

课题组网站:http://www.ibp.cas.cn/qinylab/

简       历:

  1995 - 1999  南开大学,生物学学士

  2000 - 2006  德国马-普学会,博士学位,留任博士后

  2006 -           中国科学院生物物理研究所研究员,RNA平台首席技术专家

  2014 -           中国科学院大学,岗位教授

获奖及荣誉:

 

社会任职:

 

研究方向:

  1. 核糖体的结构和分子机理

  蛋白质的生物合成过程是生命体中的核心反应,即遗传信息传递到蛋白质的全过程。 "核糖体"在所有细胞中负责合成蛋白质-蛋白质工厂,我们研究的课题包括DNA对蛋白质表达的影响、mRNA研究、蛋白质在核糖体中的合成(核心课题)、新生肽链的折叠等方向,以及蛋白质生物合成的主要抑制剂--抗生素的研发。

  2. 干细胞中的蛋白质翻译调控与疾病(癌症、病毒性肺炎、肺纤维化等)

  我们研究癌症的发生、恶化以及转移过程;病毒性肺炎、肺纤维化与肺部造血干细胞对蛋白质翻译过程依赖的分子机制,从而建立疾病模型,进而为相关疾病的诊断、治疗提出新方案。

  研究工作进展:

  我们发现核糖体的"倒退"(Qin et al., Cell, 2006)及其诱导因子EF4 (Qin*, Nature Structural & Molecular Biology, 2008, 2012, 2014, 2016a,b)在人类肿瘤、小鼠、线虫以及大肠杆菌中的生理功能与病理意义。

  在Cell, Nature 系列(Nature Reviews Microbiology, Nature Structural & Molecular Biology 等),PNAS等学术杂志以(唯一或共同)第一作者、通讯作者发表研究论文30余篇,并拥有多项专利。以首席科学家、项目负责人等身份执行\完成了科技部重点研发计划(首席科学家、项目负责人、参与骨干)3次,自然科学基金委重点项目(负责人)、优青、面上项目(负责人)5次、中国科学院重点项目(负责人、参与骨干)、先导项目(子课题负责人)3次等。

承担项目情况:

 

代表论著:

  1. Song G, Xu B, Shi H, Zhang Y, Zhang D, Cao X, Liu Z, Guo R, Guan Y, Chu Y, Zhang X*, Lou J*, and Qin Y*. (2020) (*corresponding author) Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF, International Journal of Biological Macromolecules. DOI: BIOMAC 15737

  2. Zhang K, Bai X, Yuan Z, Cao Xintao, Jiao X, Qin Y*, Wen Y* and Zhang X. (2020) (*corresponding author) Cellular Nanofiber Structure with Secretory Activity-Promoting Characteristics for Multicellular Spheroid Formation and Hair Follicle Regeneration, ACS Appl. Mater. Interfaces. 2020, 12, 7, 7931-7941 (https://pubs.acs.org/doi/10.1021/acsami.9b21125) (IF 8.456)

  3. Zhang K, Bai X, Yuan Z, Cao Xintao, Jiao X, Qin Y*, Wen Y* and Zhang X. (2019) (*corresponding author) Layered nano?ber sponge with an improved capacity for promoting blood coagulation and wound healing, Biomateirals. (204 (2019) 70-79 ) (IF 10.273)

  4. Zhou Z, Hu Y, Li A, Li Y, Zhao H, Wang S, Otecko NO, Zhang D, Wang J, Liu Y, Irwin DM, Qin Y & Ya-Ping Zhang* (2018) Genome wide analyses uncover allele-specific RNA editing in human and mouse,Nucleic Acids Res. https://doi.org/10.1093/nar/gky613

  5. Wang F, Zhang L, Bai X, Cao X, Jiao X, Huang Y, Li Y, Qin Y* and Wen Y* (2018) (*corresponding author) Stimuli-Responsive Nanocarrier for Co-delivery of MiR-31 and Doxorubicin To Suppress High MtEF4 Cancer, ACS Applied Materials & Interfaces. doi: 10.1021/acsami.8b07698

  6. Zhu P, Liu Y, Zhang F, Bai X, Chen Z, Shangguan F, Zhang B, Zhang L, Chen Q, Xie D, Lan L, Xue X, Liang X, LU B, Wei T, Qin Y* (2018) (*corresponding author) Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch. Cancer Research. (78(11); 2813-24 ) (IF 9.122)

  7. Gao Y, Bai X, Zhang D, Han C,Yuan J, Liu W, Cao X, Chen Z, Shangguan F, Zhu Z, Gao F and Qin Y* (2016) (*corresponding author) Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis, Nat Struct Mol Biol. 10.1038/nsmb.3206 (IF 13.309)

  8. Zhang D, Kaige Y, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Lou Z, Gao N* and Qin Y* (2016) (*corresponding author) EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome, Nat Struct Mol Biol. 23, 125-131 (IF 13.309)

  9. Zhang D, Kaige Y, Zhang Y, Liu G, Cao X, Song G, Xie Q*, Gao N*, Qin Y* (2015) (*corresponding author) New insights into the enzymatic role of EF-G in ribosome recycling, Nucleic Acids Res. 1674-1683.

  10. Liu G, Zhang D, Song G, Li Z, Zhang D, Lyv Z, Aachenbach J, Dong J, Gong W, Zhao X, Nierhaus K H and Qin Y* (2014) (*corresponding author) EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex, Nat Struct Mol Biol. 21, 817-824. (IF 13.309)

  11. Yamamoto H#, Qin Y#, Achenhach J#, Li X, Kijek J, Kijek J, Sphan CMT and Nierhaus HK (2014) (#co-first author) EF-G and EF4: Translocation and back-translocation on the bacterial ribosome. Nature Reviews Microbiology. 12 (2) 89-100 (Invited review). (IF 22.49)

  Nominated by "Faculty of 1000"

  12. Zhang D, Liu G, Xue J, Lou J, Nierhaus K H, Gong W* and Qin Y* (2012) (*corresponding author) Common chaperone activity in the G-domain of trGTPase protects L11-L12 interaction on the ribosome, Nucleic Acids Res., 40 (21) 10851-10865. (IF 8.026)

  13. Wang L, Yang F, Zhang D, Chen Z, Xu R, Nierhaus K H, Gong W and Qin Y* (2012) (*corresponding author) A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases, Nat. Struct. Mol. Biol., 19(4)403-410 (IF12.712)

  14. Di Giacco V#, Marquez V#, Qin Y#, Pech M, Triana-Alonso FJ, Wilson DN, Nierhaus KH (2008) (#co-first author). Shine-dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. PNAS. 105(31):10715-10720. (IF 9.681)

  15. Connell SR#, Topf M#, Qin Y#, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM (2008) (#co-first author) A new trna intermediate revealed on the ribosome during ef4-mediated back-translocation. Nature Struct. Mol. Biol. 15(9):910-915. (IF 12.712).

  16. Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH (2006) The highly conserved lepa is a ribosomal elongation factor that back-translocates the ribosome. Cell 127(4):721-733. (IF 32.403)

  Commented by Current Biology (Youngman et al., 17 (4)316-319)

  Evaluated by "Faculty of 1000" (http://f1000.com/prime/1089479)  

专      利:

  1. Knud H Nierhaus, Yan Qin; Daniel Wilson. The protein factor LepA (EF4) as a new target for antibiotics against bacteria. PCT/EP 2007/008961

  2. Knud H Nierhaus, Yan Qin; Daniel Wilson. Use of LepA for improving the accuracy of protein synthesis in vitro. PCT/EP 2006/006503 

  3. Yan Qin, Yanyan Gao. Usage of the mitochondrial translation factor Guf1 in Male sterility study. 2013104852275

  4. 秦燕,郝佳,朱萍. EF4蛋白编码基因沉默在癌症治疗方面的应用(申请号:201210566942.7,证书号第2369805号)(已授权)

  5. 秦燕, 高岩岩. 线粒体蛋白质翻译因子mtEF4/Guf1在雄性不育研究中的应用(申请号201310485227.5 ,证书号第1812912号)(已授权)

  6. 秦燕,白秀峰. 人mtEF4过表达腺相关病毒用于毛发生长和诊断脱发生物标志物(申请中)

(资料来源:秦燕研究员,2020-06-15)