
中国科学院生物物理研究所,表观遗传调控与干预全国重点实验室 2025年入选北京"高创计划"-青年人才托举工程
2011.09 - 2015.06 山东第一医科大学,生物技术,学士学位
2015.09 - 2017.06 南京医科大学,免疫学,硕博连读
2017.09 - 2020.06 南京医科大学,生化与分子生物学,博士学位
2020.08 - 2023.12 中国科学院生物物理研究所,博士后
2024.01 - 2024.12 中国科学院生物物理研究所,表观遗传调控与干预重点实验室,助理研究员
2025.01 - 至今 中国科学院生物物理研究所,表观遗传调控与干预重点实验室,副研究员
聚焦具有代谢重编程功能的代谢物,解析免疫细胞对其感知与解码机制;阐明代谢物介导细胞间通讯的普适性规律,为抗感染、抗肿瘤及慢性炎症治疗提供新靶点。
1. Zhang ZX#, Chen C#, Liu CY, Sun PK, Liu P, Fang S, Li XJ*. Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation. Science Advances 2025; 11(10): eadq4266
2. Chen C#, Liu CY#, Sun PK#, Zhang ZX, Wang ZM, Liu P, Li XJ*. Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity. Developmental Cell 2024; 59(21): 2807-2817
3. Chen C#, Zhang ZX#, Liu CY#, Sun PK, Liu P, Li XJ*. ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis. Cell Metabolism 2024; 36(3): 498-510
4. Zhang ZX#, Chen C#, Yang F, Zeng Y-X, Sun PK, Liu P, Li XJ*. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. Molecular Cell 2022; 82(15): 2844-2857
5. Sun PK#, Zhang ZX#, Wang B, Liu CY, Chen C, Liu P, Li XJ*. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nature Communications 2022; 13(1): 6562
6. Chen C#, Zhang ZX#, Liu CY, Wang B, Liu P, Fang S, Yang F, You YP, Li XJ*. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Nature Communications 2022; 13(1): 6108
7. Zhang ZX#, Li X#, Yang F#, Chen C#, Liu P, Ren Y, Sun PK, Wang ZX, You YP, Zeng Y-X, Li XJ*. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis. Nature Communications 2021; 12(1): 5872
8. Chen C#, Zhu SC#, Zhang X, Zhou TT, Gu J, Xu YR, Wan Q, Qi X, Chai YZ, Liu XR, Chen LK, Yan J, Hua YF, Lin F*. Targeting the synthetic vulnerability of PTEN-deficient glioblastoma cells with MCL1 inhibitors. Molecular Cancer Therapeutics 2020; 19(10): 2001-2011
9. Chen C#, Zhai SL#, Zhang L, Chen JJ, Long XH, Qin J, Li JH, Huo R, Wang XM*. Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection. Journal of Experimental Medicine 2018; 215(5): 1437-1448
1. Chen C#, Li XJ*. The cell autonomous and non-autonomous roles of itaconate in immune response. Cell Insight 2025; 4(1): 100224.
(资料来源:陈超副研究员,2026-10-13)