Signal Transduction and Targeted Therapy, 4 January, 2023, DOI：https://doi.org/10.1038/s41392-022-01276-5
ADAR1: a mast regulator of aging and immunity
Yigan Zhang, Jinyue Zhang & Yuanchao Xue
Recently, Nature and Nature Cell Biology published five papers on the function and molecular mechanism of ADAR1 (adenosine deaminases acting on RNA) in aging, cancer, and autoimmune diseases. Among them, four papers published in Nature revealed that ADAR1 regulates autoimmune disease and cancer immunotherapy through canonical adenosine-to-inosine (A-to-I) RNA editing. Using a different approach, the paper in Nature Cell Biology discovered that ADAR1 could suppress senescence by regulating p16 INK4a expression through an RNA editing independent non-canonical pathway.