Journal of Hepatology, 5 November, 2020, DOI：https://doi.org/10.1016/j.jhep.2020.05.039
Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma
Min Zhang, HuiYang, Lingfei Wan, Zhaohai Wang, Haiyang Wang, Chen Ge, Yunhui Liu, Yajing Hao, Dongdong Zhang, Gaona Shi, Yandong Gong, YanliNi, Chaojie Wang, Yuan Zhang, Jiafei Xi, Sen Wang, Lei Shi, Lina Zhang…Xinlong Yan
Intrahepatic cholangiocarcinoma (ICC) is the second most common aggressive and chemotherapy-refractory liver malignancy. Over the past decade, it has become a significant global concern due to its increasing diagnostic incidence and accompanying mortality rates. The majority of patients have already reached advanced-stage disease at the time of diagnosis and only a few patients are suitable for curative hepatic resection. Moreover, the recurrence rate after surgical resection remains high, only 5% of patients survive beyond 5 years, and the prognosis is extremely poor for patients with unresectable ICC due to the lack of available treatment options.