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An electron transfer path connects subunits of a mycobacterial respiratory supercomplex, Science, 30 Nov 2018

发布时间:2018年11月30日

Science, 30 November, 2018, DOI: http://dx.doi.org/10.1126/science.aat8923

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

Hongri Gong1,*, Jun Li2,3,*, Ao Xu1,4,*, Yanting Tang1, Wenxin Ji4,5, Ruogu Gao4,5, Shuhui Wang2,3, Lu Yu6, Changlin Tian6,7, Jingwen Li8, Hsin-Yung Yen8,9, Sin Man Lam10, Guanghou Shui10, Xiuna Yang2,3, Yuna Sun4, Xuemei Li4, Minze Jia4, Cheng Yang1, Biao Jiang2, Zhiyong Lou11, Carol V. Robinson8, Luet-Lok Wong12, Luke W. Guddat13, Fei Sun4,5, Quan Wang4, Zihe Rao1,2,3,4,11

Abstract

We report a 3.5-angstrom-resolution cryo–electron microscopy structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis.

文章链接:http://science.sciencemag.org/content/362/6418/eaat8923

 

 

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