Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch, Cancer Res, 3 June 2018
发布时间：2018年06月05日
The EMBO Journal, 3 June 2018，78(11); 2813–24，DOI: 10.1158/0008-5472.CAN-17-2059
Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch
Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, Fugen Shangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, Deyao Xie, Linhua Lan, Xiangdong Xue, Xing-Jie Liang, Bin Lu, Taotao Wei and Yan Qin
Abstract
Mitochondria regulate cellular bioenergetics and redox states and influence multiple signaling pathways required for tumorigenesis. In this study, we determined that the mitochondrial translation elongation factor 4 (EF4) is a critical component of tumor progression. EF4 was ubiquitous in human tissues with localization to the mitochondria (mtEF4) and performed quality control on respiratory chain biogenesis. Knockout of mtEF4 induced respiratory chain complex defects and apoptosis, while its overexpression stimulated cancer development. In multiple cancers, expression of mtEF4 was increased in patient tumor tissues. These findings reveal that mtEF4 expression may promote tumorigenesis via an imbalance in the regulation of mitochondrial activities and subsequent variation of cellular redox. Thus, dysregulated mitochondrial translation may play a vital role in the etiology and development of diverse human cancers.
附件下载：
Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch, Cancer Res, 3 June 2018
The EMBO Journal, 3 June 2018，78(11); 2813–24，DOI: 10.1158/0008-5472.CAN-17-2059
Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch
Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, Fugen Shangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, Deyao Xie, Linhua Lan, Xiangdong Xue, Xing-Jie Liang, Bin Lu, Taotao Wei and Yan Qin
Abstract
Mitochondria regulate cellular bioenergetics and redox states and influence multiple signaling pathways required for tumorigenesis. In this study, we determined that the mitochondrial translation elongation factor 4 (EF4) is a critical component of tumor progression. EF4 was ubiquitous in human tissues with localization to the mitochondria (mtEF4) and performed quality control on respiratory chain biogenesis. Knockout of mtEF4 induced respiratory chain complex defects and apoptosis, while its overexpression stimulated cancer development. In multiple cancers, expression of mtEF4 was increased in patient tumor tissues. These findings reveal that mtEF4 expression may promote tumorigenesis via an imbalance in the regulation of mitochondrial activities and subsequent variation of cellular redox. Thus, dysregulated mitochondrial translation may play a vital role in the etiology and development of diverse human cancers.
文章链接：http://cancerres.aacrjournals.org/content/78/11/2813
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