Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4, Nat Commun, 742, 21 Feb 2018
发布时间：2018年02月23日
Nature Communications, 742, 21 Feb 2018，DOI: 10.1038/s41467-018-03128-9
Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
Ning Lu, Ying Li, Zhiqiang Zhang, Junji Xing, Ying Sun, Sheng Yao & Lieping Chen
Abstract
Semaphorin-4A (Sema4A) has been implicated in the co-stimulation of T cells and drives Th1 immune responses by binding to the receptor T-cell immunoglobulin and mucin domain protein 2 (Tim-2) in mice. Here we show that human, but not murine, Sema4A is preferentially expressed on antigen-presenting cells, and co-stimulates CD4+ T-cell proliferation and drives Th2 responses. By employing two independent cloning strategies, we demonstrate that Immunoglobulin-like transcript 4 (ILT-4) is a receptor for human SEMA4A (hSEMA4A) on activated CD4+ T cells. We also find hSEMA4A to be highly expressed in human asthmatic lung tissue, implying its potential function in disease pathogenesis. Our study defines a different biological function of hSEMA4A from its murine homolog through its binding to the receptor of ILT-4 to co-stimulate CD4+T cells and regulate Th2 cells differentiation.
附件下载：
Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4, Nat Commun, 742, 21 Feb 2018
Nature Communications, 742, 21 Feb 2018，DOI: 10.1038/s41467-018-03128-9
Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
Ning Lu, Ying Li, Zhiqiang Zhang, Junji Xing, Ying Sun, Sheng Yao & Lieping Chen
Abstract
Semaphorin-4A (Sema4A) has been implicated in the co-stimulation of T cells and drives Th1 immune responses by binding to the receptor T-cell immunoglobulin and mucin domain protein 2 (Tim-2) in mice. Here we show that human, but not murine, Sema4A is preferentially expressed on antigen-presenting cells, and co-stimulates CD4+ T-cell proliferation and drives Th2 responses. By employing two independent cloning strategies, we demonstrate that Immunoglobulin-like transcript 4 (ILT-4) is a receptor for human SEMA4A (hSEMA4A) on activated CD4+ T cells. We also find hSEMA4A to be highly expressed in human asthmatic lung tissue, implying its potential function in disease pathogenesis. Our study defines a different biological function of hSEMA4A from its murine homolog through its binding to the receptor of ILT-4 to co-stimulate CD4+T cells and regulate Th2 cells differentiation.
文章链接：https://www.nature.com/articles/s41467-018-03128-9