Natural-Killer-like B Cells Function as a Separate Subset of Innate B Cells
Shuo Wang, Pengyan Xia, Zusen Fan
Abstract
We appreciate the comments made by Vivier and colleagues on our findings of natural-killer-like (NKB) cells. We identified a separate subpopulation of innate B cells (called NKB cells) that have CD19+NK1.1+ signature markers and mainly reside in the spleen and mesenteric lymph nodes (MLNs) (Wang et al., 2016). We found that NKB cells harbor a unique identity that is distinct from those of NK and B cells. NKB cells can produce large amounts of interleukin-18 (IL-18) and IL-12 at an early phase of infection and consequently activate type 1 innate lymphoid cells (ILC1s) and NK cells to initiate innate immunity against invading microorganisms.
附件下载：
Natural-Killer-like B Cells Function as a Separate Subset of Innate B Cells, Immunity, Volume 47, Issue 2, p201–202, 15 August 2017
Immunity, Volume 47, Issue 2, p201–202, 15 August 2017, DOI: http://dx.doi.org/10.1016/j.immuni.2017.07.023
Natural-Killer-like B Cells Function as a Separate Subset of Innate B Cells
Shuo Wang, Pengyan Xia, Zusen Fan
Abstract
We appreciate the comments made by Vivier and colleagues on our findings of natural-killer-like (NKB) cells. We identified a separate subpopulation of innate B cells (called NKB cells) that have CD19+NK1.1+ signature markers and mainly reside in the spleen and mesenteric lymph nodes (MLNs) (Wang et al., 2016). We found that NKB cells harbor a unique identity that is distinct from those of NK and B cells. NKB cells can produce large amounts of interleukin-18 (IL-18) and IL-12 at an early phase of infection and consequently activate type 1 innate lymphoid cells (ILC1s) and NK cells to initiate innate immunity against invading microorganisms.
文章链接：http://www.cell.com/immunity/abstract/S1074-7613(17)30330-8