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HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression.Cell Host Microbe. 2015 Jul 22. pii: S1931-3128(15)00266-8.

发布时间:2015年08月11日

Cell Host Microbe, 2015 Jul 22. pii: S1931-3128(15)00266-8. doi: 10.1016/j.chom.2015.06.018. [Epub ahead of print]

HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression.

Mu X1, Fu Y2, Zhu Y3, Wang X1, Xuan Y1, Shang H2, Goff SP3, Gao G4.

Author information1CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.2Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.3Department of Biochemistry and Molecular Biophysics, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, Columbia University Medical Center, Columbia University, New York NY, 10032, USA.4CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: gaogx@moon.ibp.ac.cn.

Abstract

The correct ratio of the HIV-1 structural protein Gag to the envelope protein (Env) is important for maximal virion infectivity. How the virus ensures the production of Gag and Env proteins in an appropriate ratio remains unknown. We report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env for efficient production of infectious virions. RVB2 inhibits Gag expression by interacting with both the encoded Matrix (MA) domain of Gag protein and 5' UTR of the translating mRNA and promoting mRNA degradation in a translation-dependent manner. This inhibitory activity of RVB2 is antagonized by Env through competitive interaction with MA, allowing Gag synthesis to proceed when Env levels are adequate for virion assembly. In HIV-1-positive patients, RVB2 levels positively correlate with viral loads and disease progression status. These findings reveal a mechanism by which HIV-1 regulates its protein expression.

文章链接:http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00266-8

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