Autophagy activity contributes to programmed cell death in Caenorhabditis elegans, Autophagy，Published Online，9.27.2013
发布时间：2013年11月07日
Autophagy，Published Online，9.27.2013
Autophagy activity contributes to programmed cell death in Caenorhabditis elegans
Haibin Wang, Qun Lu, Shiya Cheng, Xiaochen Wang, Hong Zhang*
Abstract
The physiological relationship between autophagy and programmed cell death during C. elegans development is poorly understood. In C. elegans, 131 somatic cells and a large number of germline cells undergo programmed cell death. Autophagy genes function in the removal of somatic cell corpses during embryogenesis. Here we demonstrated that autophagy activity participates in germ-cell death induced by genotoxic stress. Upon γ ray treatment, fewer germline cells execute the death program in autophagy mutants. Autophagy also contributes to physiological germ-cell death and post-embryonic cell death in ventral cord neurons when ced-3 caspase activity is partially compromised. Our study reveals that autophagy activity contributes to programmed cell death during C. elegans development.
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Autophagy activity contributes to programmed cell death in Caenorhabditis elegans, Autophagy，Published Online，9.27.2013
Autophagy，Published Online，9.27.2013
Autophagy activity contributes to programmed cell death in Caenorhabditis elegans
Haibin Wang, Qun Lu, Shiya Cheng, Xiaochen Wang, Hong Zhang*
Abstract
The physiological relationship between autophagy and programmed cell death during C. elegans development is poorly understood. In C. elegans, 131 somatic cells and a large number of germline cells undergo programmed cell death. Autophagy genes function in the removal of somatic cell corpses during embryogenesis. Here we demonstrated that autophagy activity participates in germ-cell death induced by genotoxic stress. Upon γ ray treatment, fewer germline cells execute the death program in autophagy mutants. Autophagy also contributes to physiological germ-cell death and post-embryonic cell death in ventral cord neurons when ced-3 caspase activity is partially compromised. Our study reveals that autophagy activity contributes to programmed cell death during C. elegans development.
相关报道：http://www.ibp.cas.cn/kyjz/zxdt/201311/t20131106_3968663.html
文章链接：https://www.landesbioscience.com/journals/autophagy/article/26152/