The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling, Journal Of Hepatology, 22 Dec 2018
The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling
Jiayi Wu, Pingping Zhu, Tiankun Lu, Ying Du, Yanying Wang, Luyun He, Buqing Ye, Benyu Liu, Liuliu Yang, Jing Wang, Yang Gu, Jie Lan, Yajing Hao, Lei He, Zusen Fan
Introduction
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is one of the leading causes of cancer death globally. The highest incidence of HCC is in East and South-East Asia and Northern and Western Africa.1 However, the incidence of liver cancer, including HCC, has risen in areas with historically low rates, for instance, Western Europe, Northern America and parts of Oceania. Infection with hepatitis B virus and hepatitis C virus, as well as metabolic disorders, are etiologically responsible for HCC.2 The high rate of recurrence and heterogeneity render HCC intractable.3 Therefore, the mechanism underlying liver carcinogenesis remain elusive.
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The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling, Journal Of Hepatology, 22 Dec 2018
Journal Of Hepatology, 22 December, 2018， DOI: http://dx.doi.org/10.1016/j.jhep.2018.12.015
The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling
Jiayi Wu, Pingping Zhu, Tiankun Lu, Ying Du, Yanying Wang, Luyun He, Buqing Ye, Benyu Liu, Liuliu Yang, Jing Wang, Yang Gu, Jie Lan, Yajing Hao, Lei He, Zusen Fan
Introduction
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is one of the leading causes of cancer death globally. The highest incidence of HCC is in East and South-East Asia and Northern and Western Africa.1 However, the incidence of liver cancer, including HCC, has risen in areas with historically low rates, for instance, Western Europe, Northern America and parts of Oceania. Infection with hepatitis B virus and hepatitis C virus, as well as metabolic disorders, are etiologically responsible for HCC.2 The high rate of recurrence and heterogeneity render HCC intractable.3 Therefore, the mechanism underlying liver carcinogenesis remain elusive.
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