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A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice, Science 26 June 2015: Vol. 348 no. 6242 pp. 1472-1477

发布时间:2015年06月28日

Science 26 June 2015: Vol. 348 no. 6242 pp. 1472-1477, DOI: 10.1126/science.aaa8694

A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice

Congping Shang1,2, Zhihui Liu1, Zijun Chen1,2, Yingchao Shi1,2, Qian Wang1, Su Liu1, Dapeng Li1, Peng Cao1*

Abstract

The fear responses to environmental threats play a fundamental role in survival. Little is known about the neural circuits specifically processing threat-relevant sensory information in the mammalian brain. We identified parvalbumin-positive (PV+) excitatory projection neurons in mouse superior colliculus (SC) as a key neuronal subtype for detecting looming objects and triggering fear responses. These neurons, distributed predominantly in the superficial SC, divergently projected to different brain areas, including the parabigeminal nucleus (PBGN), an intermediate station leading to the amygdala. Activation of the PV+ SC-PBGN pathway triggered fear responses, induced conditioned aversion, and caused depression-related behaviors. Approximately 20% of mice subjected to the fear-conditioning paradigm developed a generalized fear memory.

文章链接:http://www.sciencemag.org/content/348/6242/1472.full

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201506/t20150626_4380344.html

 

 

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