The Long Noncoding RNA lncTCF7 Promotes Self-Renewal..... Cancer Stem Cells through Activation of Wnt Signaling，Cell Stem Cell, Vol.16, Issue 4, 2 April 2015
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an lncRNA-based Wnt signaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that lncRNAs can play in tumor growth and propagation.
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The Long Noncoding RNA lncTCF7 Promotes Self-Renewal..... Cancer Stem Cells through Activation of Wnt Signaling，Cell Stem Cell, Vol.16, Issue 4, 2 April 2015
Cell Stem Cell, Volume 16, Issue 4, 2 April 2015, Pages 413–425，doi:10.1016/j.stem.2015.03.003
The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling
Yanying Wang1, 5 , Lei He 2, 5, Ying Du1, Pingping Zhu1, Guanling Huang1, 3, Jianjun Luo4, Xinlong Yan1, Buqing Ye1, Chong Li1, Pengyan Xia1, Geng Zhang1, Yong Tian4, Runsheng Chen4, Zusen Fan1, 3
Summary
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an lncRNA-based Wnt signaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that lncRNAs can play in tumor growth and propagation.
相关报道：http://www.ibp.cas.cn/kyjz/zxdt/201504/t20150403_4332003.html
文章链接：http://www.sciencedirect.com/science/article/pii/S1934590915001149