Cell Research, 2013 Jun 18. doi: 10.1038/cr.2013.80. [Epub ahead of print]
Crystal structure and nucleotide selectivity of human IFIT5/ISG58.
Feng F, Yuan L, Wang YE, Crowley C, Lv Z, Li J, Liu Y, Cheng G,Zeng S, Liang H.
State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Abstract
Interferon-stimulated gene 56 (ISG56) family members, ISG56, ISG54, ISG58 and ISG60, also known as interferon-induced protein with tetratricopeptide repeats (TPR) 1 (IFIT1), IFIT2, IFIT5 and IFIT3, respectively, play crucial roles in human antiviral defense systems. Recent studies have shown that ISG56 specifically recognizes viral 5′-pppRNA3, we hypothesize that different ISG56 family members likely recognize distinct substrates.
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全文链接：http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201380a.html
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