Autophagic control of cell ‘stemness’，EMBO Molecular Medicine, Volume 5, Issue 3, pages 327–331, March 2013

EMBO Molecular Medicine, Volume 5, Issue 3, pages 327–331, March 2013, Article first published online: 5 MAR 2013，DOI: 10.1002/emmm.201201999

Autophagic control of cell ‘stemness’

Huize Pan ^1, , Ning Cai ^1, , Mo Li2, Guang-Hui Liu ^1,* , Juan Carlos Izpisua Belmonte ^2,3,*

Author Information

¹ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

² Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA

³ Center for Regenerative Medicine in Barcelona, Barcelona, Spain

These authors contributed equally to this work.

Email: Guang-Hui Liu (ghliu@ibp.ac.cn), Juan Carlos Izpisua Belmonte (belmonte@salk.edu; izpisua@cmrb.eu)

* Tel: +86 10 64888315; Fax: +86 10 64889970

These authors contributed equally to this work.

Abstract

Stem cells have the ability to self-renew and differentiate into various cell types. Both cell-intrinsic and extrinsic factors may contribute to aging-related decline in stem cell function and loss of stemness. The maintenance of cellular homeostasis requires timely removal of toxic proteins and damaged organelles that accumulate with age or in pathological conditions. Autophagy is one of the main strategies to eliminate unwanted cytoplasmic materials thereby ultimately preventing cellular damage. Here, we shall discuss the accumulating evidence suggesting that autophagy plays a critical role in the homeostatic control of stem cell functions during aging, tissue regeneration, and cellular reprogramming.

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