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2008年学术活动

学术报告

发布时间:2008年07月11日

 

学术报告

报告题目:Pushing the envelope of cryo-electron tomography: from cells to molecules

人:Liu Jun, Ph.D.
Assistant Professor, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School

  点:生物物理研究所图书馆二层报告厅

  间:2008716日(周三)2:30 p.m.

Selected publications

1. Liu J, Bartesaghi A, Borgnia M, Sapiro G, Subramaniam S: Structure of native HIV-1 gp120 trimers in unliganded and CD4-liganded states. Nature, in press.

2. Liu J, Taylor DW, Krementsova EB, Trybus KM, Taylor KA: Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography. Nature 2006, 442:208-211.

3. Zhu P, Liu J, Bess J, Jr., Chertova E, Lifson JD, Grise H, Ofek GA, Taylor KA, Roux KH: Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 2006, 441:847-852.

4. Zhu P, Chertova E, Bess J, Jr., Lifson JD, Arthur LO, Liu J, Taylor KA, Roux KH: Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. PNAS 2003, 100:15812-15817.

5.Miao L, Vanderlinde O, Liu J, Grant R, Wouterse A, Philipse A, Stewart M, Roberts TM: Filament packing constraints generate protrusive force in amoeboid cell motility. PNAS 2008 105:5390-5.

6. Liu J, Wendt T, Taylor D, Taylor K: Refined model of the 10S conformation of smooth muscle myosin by cryo-electron microscopy 3D image reconstruction. J Mol Biol 2003, 329:963-972.

7. Liu J, Taylor DW, Taylor KA: A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region. J Mol Biol 2004, 338:115-125.

8.Liu J, Wu S, Reedy MC, Winkler H, Lucaveche C, Cheng Y, Reedy MK, Taylor KA: Electron tomography of swollen rigor fibers of insect flight muscle reveals a short and variably angled S2 domain. J Mol Biol 2006, 362:844-860.

9. Liu J, McBride MJ, Subramaniam S: Cell-surface filaments of the gliding bacterium Flavobacterium johnsoniae revealed by cryo-electron tomography. J Bacteriol 2007 189: 7503-7506.

10. Liu J, Reedy MC, Goldman YE, Franzini-Armstrong C, Sasaki H, Tregear RT, Lucaveche C, Winkler H, Baumann BA, Squire JM, Irving TC, Reedy MK, Taylor KA: Electron tomography of fast frozen, stretched rigor fibers reveals elastic distortions in the myosin crossbridges. J Struct Biol 2004, 147:268-282.

 

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