Roberto Sitia has worked in Genoa, New York (USA) and Cambridge (UK). He is Professor of Cell and Molecular Biology at the Medical School, Università Vita-Salute San Raffaele. Member of EMBO and co-founder of European Life Sciences Organisation (ELSO), he serves as an Editor of EMBO J., EMBO Reports and J. Biol. Chem. He studied the regulation of antibody production (isotype switching, H chain splicing and secretion). He discovered and characterised the thiol-mediated retention and degradation of proteins synthesized in the endoplasmic reticulum and the 'leaderless' secretory pathway, utilized by proteins that lack a signal peptide. Recently, his laboratory has cloned several novel human genes involved in the UPR and the control of disulfide bond formation in the ER.