范克龙课题组

简       历：

　2007-2011年 东北农业大学动物医学学院 获农学学士学位

　2011-2014年 东北农业大学动物医学学院 获农学硕士学位

　2014-2019年 清华大学 获工学博士学位

　2019年-至今   中国科学院生物物理研究所 博士后

获奖及荣誉：

社会任职：

研究方向：

   目前的纳米酶在生物医学应用中的首要挑战在于如何赋予其病灶靶向性，以避免非特异性结合影响纳米酶在靶组织的催化活性并引起全身的毒副作用。为此，我们将基于多肽纳米药物和铁蛋白药物载体的研究背景，精准设计环境响应性的靶向自组装多肽纳米酶用于生物医学研究，利用多功能多肽自组装成纳米颗粒，并生物矿化合成纳米酶，形成环境响应的智能化纳米酶，进一步深入研究不同结构纳米酶的活性及其催化机制，根据构效关系对纳米酶进行理性设计，更高效地发挥纳米酶催化功能，降低纳米酶的非特异性吸附和毒副作用，有利于提高疗效并满足预后需求。在生物医学领域具有广阔的应用前景。

承担项目情况：

　1.中国科学院特别研究助理资助项目（2019），2020.1-2021.12，主持。

　2.中国博士后科学基金面上项目二等资助（2019M660826），2020.1-2021.12，主持。

代表论著：

　1.Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan,* and Kelong Fan*. Bioengineered dual-targeting protein nanocage for stereoscopically loading of synergistic hydrophilic/hydrophobic drugs to enhance anticancer efficacy. Adv. Funct. Mater. 2021, 2102004.

　2.Zhuoran Wang#, Ruofei Zhang#, Xiyun Yan*, Kelong Fan*. Structure and activity of nanozymes: Inspirations for de novo design of nanozymes. (#Co-first author) Materials Today 2020, 41: 81-119.

　3.Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019, 6, 1900586.

　4.Zhuoran Wang, Jianwen Guo, Xinyu Liu, Jiawei Sun, Weiping Gao*. Temperature-triggered micellization of interferon alpha-diblock copolypeptide conjugate with enhanced stability and pharmacology. J. Control. Release 2020, 328, 444-453.

　5.Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao*. One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2018, 7, 104-112.

　6.Zhuoran Wang#, Qiong He#, Wenguo Zhao, Jianwen Luo*, Weiping Gao* Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. (#Co-first author) J. Control. Release 2017, 264, 66-75.

　7.Liang, P., Wang, G., Liu, X., Wang, Z., Wang, J. & Gao, W. Spatiotemporal combination of thermosensitive polypeptide fused interferon and temozolomide for post-surgical glioblastoma immunochemotherapy. Biomater. 2021, 264, 120447 .

　8.Jianwen Guo; Jiawei Sun; Xinyu Liu; Zhuoran Wang; Weiping Gao*. Head-to-tail macrocyclization of albumin-binding domain fused interferon alpha improves the stability, activity, tumor penetration, and pharmacology. Biomaterials, 2020, 250: 120073.

　9.Xinyu Liu; Mengmeng Sun; Jiawei Sun; Jin Hu; Zhuoran Wang; Jianwen Guo; Weiping Gao*. Polymerization Induced Self-Assembly of a Site-Specific Interferon α-Block Copolymer Conjugate into Micelles with Remarkably Enhanced Pharmacology. Journal of the American Chemical Society, 2018, 140(33): 10435-10438.

　10.Linjia Su; Song Hu; Li Zhang; Zhuoran Wang; Weiping Gao; Jing Yuan; Minghua Liu*. A Fast and Efficient Replacement of CTAB with MUA on the Surface of Gold Nanorods Assisted by a Water-Immiscible Ionic Liquid. Small, 2017, 13(11).

　11.Xinyu Liu; Jin Hu; Zhuoran Wang; Zhikun Xu; Weiping Gao*. Polypeptides and Engineered Proteins. Advances in Bioinspired and Biomedical Materials Volume 1. ACS Symposium Series, 2017.

　12.高卫平，王卓然. 一种环境刺激响应性蛋白质高分子偶联物自组装体及其制备方法与应用，专利号 201910438304.9.

　13.高卫平，王卓然. 一种温度和酶双重响应性蛋白质高分子偶联物及其制备方法与应用，专利号 201910361428.1.

　14.高卫平，王卓然. 温敏性长效缓释药物载体及其应用，专利号 201810744742.3.