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研究组长

丁璟珒博士研究员博士生导师

国家“优秀青年基金”获得者
中科院生物物理所，生物大分子国家重点实验室，研究组长

研究方向：病原菌感染和宿主天然免疫防御的分子机理

电子邮件：jding@ibp.ac.cn

电话：010-64888548

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_xsszmA_G/202005/t20200519_341420.html

简历：

　　1999 - 2003 武汉大学生命科学学院，学士

　　2003 - 2008 中国科学院生物物理研究所，博士

　　2008 - 2010 中国科学院生物物理研究所，博士后

　　2010 - 2011 中国科学院生物物理研究所，助理研究员

　　2012 - 2016 中国科学院生物物理研究所，副研究员

　　2016 - 2017 中国科学院生物物理研究所，项目研究员

　　2013 - 2017 北京生命科学研究所，访问学者

　　2018 - 至今中国科学院生物物理研究所，研究员

获奖及荣誉：

　　2022年中国科学院青年创新促进会优秀会员

　　2020年中国细胞生物学学会细胞死亡研究分会常务委员

　　2019年国家优秀青年科学基金

　　2018年中国生物化学与分子生物学会"2016年度邹承鲁杰出研究论文奖"

　　2017年中国科学院青年创新促进会会员

社会任职：

研究方向：

　　本课题组围绕"天然免疫防御和病原菌毒力"这一主题，通过整合生物化学、结构生物学和细胞生物学等多学科技术手段，从宿主和病原两方面开展深入的机制研究，近年来重点聚焦细胞焦亡、炎症和病原菌拮抗的分子机理。

承担项目情况：

代表论著：

1. Zhong, X.^#, Zeng, H.^#, Zhou, Z.^#, Su, Y., Cheng, H., Hou, Y., She, Y., Feng, N., Wang, J., Shao, F.* & Ding, J.* (2023) Structural mechanisms for regulation of GSDMB pore-forming activity. Nature. 616, 598-605.

2. Hou, Y.^#, Zeng, H.^#, Li, Z., Feng, N., Meng, F., Xu, Y., Li, L., Shao, F.* & Ding, J.* (2023) Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat Struct Mol Biol. 30, 261-272.

3. Xu, Y., Cheng, S., Zeng, H., Zhou, P., Ma, Y., Li, L., Liu, X., Shao, F.* & Ding, J.* (2022) ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy. Nat Struct Mol Biol. 29, 67-77.

4. Xu, Y. & Ding, J.* (2022) Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ. Autophagy. 18, 2751-2753.

5. Feng, N.^#, Feng, H.^#, Wang, S., Punekar, A.S., Ladenstein, R., Wang, D.C., Zhang, Q.*, Ding, J.* & Liu, W.* (2021). Structures of heat shock factor trimers bound to DNA. iScience. 24, 102951.

6. Wang, K.^#, Sun, Q.^#, Zhong, X., Zeng, M., Zeng, H., Shi, X., Li, Z., Wang, Y., Zhao, Q., Shao, F.* & Ding, J.* (2020). Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. Cell. 180, 941-55.

7. Ding, J.*, Pan, X., Du, L., Yao, Q., Xue, J., Yao, H., Wang, D. C., Li, S.* & Shao, F.* (2019). Structural and functional insights into host death domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector. Mol Cell. 74, 922-35.

8. Ding, J.* & Shao, F.* (2018). Growing a gasdermin pore in membranes of pyroptotic cells. EMBO J. 37, e100067.

9. Ding, J. & Shao, F. (2017). SnapShot: The Noncanonical Inflammasome. Cell. 168, 544-4.

10. Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D. C.*& Shao, F.* (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 535, 111-6.

11. Wang, X., Hou, Y., Deng, K., Zhang, Y., Wang, D. C.* & Ding, J.* (2015). Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3. Structure. 23, 1087-96.

12. Feng, H.^#, Ding, J.^#, Zhu, D.^#, Liu, X., Xu, X., Zhang, Y., Zang, S., Wang, D. C.*& Liu, W.* (2014). Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins. J Am Chem Soc. 136, 14694-7.

13. Wang, W.^#, Ding, J.^#, Zhang, Y., Hu, Y.*& Wang, D. C.* (2014). Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 42, 3478-91.

14. Guo, L.^#, Ding, J.^#, Guo, R., Hou, Y., Wang, D. C.*& Huang, L.* (2014). Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. J Biol Chem. 289, 1478-90.

15. Xu, X., Wang, X., Zhang, Y., Wang, D. C.* & Ding, J.* (2013). Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III. Structure. 21, 1059-66.

16. Wang, T.^#, Ding, J.^#, Zhang, Y., Wang, D. C.* & Liu, W.* (2013). Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein. Acta Crystallogr D Biol Crystallogr. 69, 1889-900.

17. Ding, J.^#, Wang, W.^#, Feng, H., Zhang, Y. & Wang, D. C. (2012). Structural insights into the Pseudomonas aeruginosa type VI virulence effector Tse1 bacteriolysis and self-protection mechanisms. J Biol Chem. 287, 26911-20.

18. Gong, Y.^#, Zhu, D.^#, Ding, J.^#, Dou, C. N., Ren, X., Gu, L., Jiang, T. * & Wang, D. C.*(2011). Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol. 18, 1297-9.

19. Ding, J., Wang, X., Li, D. F., Hu, Y., Zhang, Y. & Wang, D. C. (2010). Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation. Biochem Biophys Res Commun. 399, 587-92.

20. Ding, J., Bao, J., Zhu, D., Zhang, Y. & Wang, D. C. (2010). Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure. J Struct Biol. 171, 309-17.

（资料来源：丁璟珒研究员，2023-08-04）