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研究组长

赵岩博士研究员博士生导师

中科院生物物理所，生物大分子国家重点实验室，研究组长

研究方向：膜蛋白的结构生物学研究

电子邮件：zhaoy@ibp.ac.cn

电话：010-64888514

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_xsszmZ/202005/t20200519_341358.html

简历：

2006 - 2010 德州学院物理系，获学士学位

2010 - 2015 中国科学技术大学 & 中科院生物物理所，获博士学位

2015 - 2019 美国俄勒冈健康与科学大学/霍华德·休斯医学研究所博士后

2020 - 至今中国科学院生物物理研究所，研究员

获奖及荣誉：

社会任职：

研究方向：

膜蛋白在所有物种的生命活动中都起着至关重要的作用，帮助物质、能量以及信号实现跨生物膜的传递。在已知的基因组测序中，30%左右的基因负责编码膜蛋白。大约50%的药物分子靶向膜蛋白，这些都显示出膜蛋白具有重要的生物学和医学研究意义。本实验室的研究方向是利用冷冻电子显微术、电生理实验以及其他生物化学手段研究神经系统中重要的膜蛋白复合物的三维结构，并阐明这些复合物工作的分子机制。

承担项目情况：

代表论著：

1. Di Wu^#, Qihao Chen^#, Zhuoya Yu^#, Bo Huang^#, Jun Zhao^#, Yuhang Wang, Jiawei Su, Feng Zhou, Rui Yan, Na Li, Yan Zhao*, Daohua Jiang*. Transport and inhibition mechanisms of human VMAT2. Nature. 2024 Feb;626(7998):427-434.

2. Yanli Dong^#, Zhuoya Yu^#, Yue Li^#, Bo Huang, Qinru Bai, Yiwei Gao, Qihao Chen, Na Li, Lingli He, Yan Zhao*. EMBO J. 2024 Jan;43(1):14-31.

3. Yiwei Gao^#, Shuai Xu^#, Xiaoli Cui^#, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang*, Yan Zhao*. Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca_V2.3. Nature Communications. 2023 Jan 31;14(1):516.

4. Yue Li^#, Tian Yuan^#, Bo Huang^#, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao*, Zhuo Huang*, Daohua Jiang*. Structure of human Na_V1.6 channel reveals Na⁺ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature Communications. 2023 Feb 23;14(1):1030.

5. Yuhang Wang^#, Chengcai Pan, Qihao Chen, Qing Xie , Yiwei Gao, Lingli He, Yue Li, Yanli Dong, Xingyu Jiang* & Yan Zhao*. Architecture and autoinhibitory mechanism of the plasma membrane Na⁺/H⁺ antiporter SOS1 in Arabidopsis. Nature Communications. 2023. Jul 26;14(1):4487.

6. Z. Zhang^#, H. Chen^#, Z. Geng^#, Z. Yu, H. Li, Y. Dong, H. Zhang, Z. Huang*, J. Jiang*, Y. Zhao*, Structural basis of ligand binding modes of human EAAT2, Nature Communications. 2022 Jun 9;13(1):3329.

7. Y. Dong^#, H. Li^#, A. Ilie^#, Y. Gao, A. Boucher, X. C. Zhang*, J. Orlowski*, Y. Zhao*, Structural basis of autoinhibition of the human NHE3-CHP1 complex, Science advances. 2022 May 27;8(21):eabn3925.

8. L. He^#, Z. Yu^#, Z. Geng^#, Z. Huang^#, C. Zhang, Y. Dong, Q. Chen, L. Sun, X. Ma, B. Huang, X. Wang, Y. Zhao, Structure, gating and pharmacology of human Ca_V3.3 channel. Nature Communications. 2022.Apr 19;13(1):2084.

9. X. Li^#, F. Xu^#, H. Xu^#, S. Zhang, Y. Gao, H. Zhang, Y. Dong, Y. Zheng, B. Yang, J. Sun, X. C. Zhang, Y. Zhao*, D. Jiang*. Structural basis for modulations of human Na_V1.3 by clinical drug and selective antagonist. Nature Communications. 2022 Mar 11;13(1):1286.

10. H. Zhang^#, J. Su^#, B. Li^#, Y. Gao, M. Liu, L. He, H. Xu, X. C. Zhang, Y. Zhao. Structure of human glycosylphosphatidylinositol transamidase. Nature Structural & Molecular Biology, 2022: 1-7

11. Yanli Dong^#, Yiwei Gao^#, Shuai Xu^# Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Bei Yang, Xuejun Cai Zhang, Daohua Jiang*, Zhuo Huang*, Y. Zhao*. Closed-state inactivation and pore-blocker modulation mechanisms of human Ca_V2.2. Cell Reports. 2021. 37, 109931.

12. Lingli He^#, Jiahui Sun^#, Yiwei Gao^#, Bin Li, Yuhang Wang, Yanli Dong, Weidong An, Hang Li, Bei Yang, Yuhan Ge, Xuejun Cai Zhang*, Yun Stone Shi* & Y. Zhao*. Kainate receptor modulation by NETO2. Nature. 2021 Nov;599(7884):325-329.

13. Yanli Dong^#, Yiwei Gao^#, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C. Zhang*, John Orlowski* & Y. Zhao*. Structure and mechanism of the human NHE1-CHP1 complex. Nature Communications. 2021. 9;12(1):3474.

14. Rong Y, Jiang J.H, Gao Y.W, Guo J.L, Song D.F, Liu W.H, Zhang M.M, Zhao Y*, Xiao B.L*, Liu Z.F*. TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells. Elife, 2021.10, e71474.

15.Y. Zhao, S. Chen, A. C. Swensen, W. J. Qian, E. Gouaux, Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Science, 2019. 364, 355-362.

16. Y. Xin, Y. Zhao, J. Zheng, H. Zhou, X. C. Zhang, C. Tian, & Y. Huang. Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion. The FASEB Journal, 2018. 32(5), 2411-2421.

17. S. Chen^#, Y. Zhao^#, Y. Wang, M. Shekhar, E. Tajkhorshid and E. Gouaux. Activation and desensitization mechanism of AMPA receptor - TARP complex by cryo-EM. Cell, 2017.170, 1234-1246.

18.Y. Zhao^#, S. Chen^#, C. Yoshioka, I. Baconguis, E. Gouaux. Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. Nature, 2016.536(7614): 108-111.　　

19. G. Mao^#, Y. Zhao^#, X. Kang, Z. Li, Y. Zhang, X. Wang, F. Sun, K. Sankaran and XC. Zhang. Crystal structure of E. coli lipoprotein diacylglyceryl transferase. Nature communications, 2016.7: 10198.　　

20. J. Heng, Y. Zhao, M. Liu, Y. Liu, J. Fan, X. Wang,Y. Zhao, and XC. Zhang. Substrate-bound structure of the E. coli multidrug resistance transporter MdfA. Cell research, 2015.25(9): 1060. 　　

21. X.C. Zhang, Y. Zhao, J. Heng, D. Jiang. Energy coupling mechanisms of MFS transporters. Protein Science, 2015.24(10): 1560-1579.　

22.Y. Zhao^#, G. Mao^#, M. Liu, L. Zhang, X. Wang, X.C. Zhang. Crystal structure of the E. coli peptide transporter YbgH. Structure, 2014.22(8): 1152-1160.　　

23. B. Cao^#, Y. Zhao^#, Y. Kou, D. Ni, X.C. Zhang and Y. Huang. Structure of the nonameric bacterial amyloid secretion channel. Proceedings of the National Academy of Sciences, 2014.111(50): E5439-E5444.　　　

24. D. Jiang^#, Y. Zhao^#, J. Fan, X. Liu, Y. Wu, W. Feng, X.C. Zhang. Atomic resolution structure of the E. coli YajR transporter YAM domain. Biochemical and biophysical research communications, 2014.450(2): 929-935.　　

25. S. Qiao, Q. Luo, Y. Zhao, X.C. Zhang, Y. Huang. Structural basis for lipopolysaccharide insertion in the bacterial outer membrane. Nature, 2014.511(7507): 108.

26. J. Fan, D. Jiang, Y. Zhao, J. Liu, and X.C. Zhang. Crystal structure of lipid phosphatase Escherichia coli phosphatidylglycerophosphate phosphatase B. Proceedings of the National Academy of Sciences, 2014.111(21): 7636-7640. 　　

27. D. Jiang^#, Y. Zhao^#, X. Wang^#, J. Fan, J. Heng, X. Liu, W. Feng, X. Kang, B. Huang, J. Liu and X.C. Zhang. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Proceedings of the National Academy of Sciences, 2014.110(36): 14664-14669.　　

28. W. Zhang, F. Zeng, Y. Liu, Y. Zhao, H. Lv, L. Niu, M. Teng and X. Li (2013). Crystal Structures and RNA-Binding Properties of the RRMs of hnRNP-L: Insights into Its Roles in Alternative-splicing Regulation. Journal of Biological Chemistry, 2014 288(31), 22636-22649.　　

（资料来源：赵岩研究员，2024-03-18）