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姓氏首字母W

王晓群  博士 研究员 博士生导师  

中科院生物物理所,脑与认知科学国家重点实验室副主任,研究组长

研究方向:神经干细胞、大脑皮层和神经环路发育,以及相关疾病

电子邮件:xiaoqun.wang@gmail.com/xiaoqunwang@ibp.ac.cn

电       话:010-64887994

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_xsszmW/202005/t20200519_5582972.json

课题组网站:http://wanglaboratory.org/

简       历:

  2009 - 2012  美国加州大学旧金山分校助理教授(研究系列)

  2012 - 至今  中国科学院生物物理研究所,研究员,博士生导师

  2015 - 至今  中国科学院大学生命学院教授

  2019 - 至今  中国科学院大学神经生物与心理教研室主任

获奖及荣誉:

  2020年  北脑学者

  2020年  中国科学院大学领雁奖章--振翅奖

  2020年  中国科学院优秀导师奖

  2019年  谈家桢生命科学创新奖

  2019年  中国科学院优秀导师奖

  2018年  干细胞研究创新奖

  2018年  中国科学院优秀导师奖

  2015年  英国牛顿高级学者奖

  2014 - 2018  国家重大科学研究计划"成体神经干细胞的命运决定机制与功能研究"首席科学家

  2019 - 2023  国家重点研发计划"区域特异性神经干细胞的获取以及功能特性和应用的研究"首席科学家

学术任职:

  中国细胞生物学会细胞治疗分会副会长

  美国神经学会动物福利伦理委员会委员

课题组学生获奖情况:

  2020年  博士生卢玉峰获得中国科学院院长优秀奖

  2019年  博士生钟穗娟获得张香桐神经科学优秀研究生论文奖

  2019年  博士生钟穗娟获得中科院院优秀博士学位论文奖

  2019年  博士生卢玉峰获得罗氏大学研究基金二等奖

  2019年  博士生刘静获得中国科学院优秀博士学位论文奖

  2019年  博士生陈睿国获得研究生国家奖学金

  2019年  博士生卢玉峰获得中国干细胞第九届年会优秀壁报二等奖

  2019年  博士生卢玉峰获得研究生国家奖学金

  2019年  硕士生卢甜获得中国科学院大学大学生奖学金

  2019年  硕士生冉庚鑫获得中国科学院大学大学生奖学金

  2018年  博士生钟穗娟获得中国科学院院长特别奖

  2018年  博士生钟穗娟获得中国科学院必和必拓奖学金

  2018年  博士生钟穗娟获得研究生国家奖学金

  2018年  博士生钟穗娟获得所长论文奖

  2018年  硕士生卢玉峰获得研究生国家奖学金

  2017年  博士生刘静获得研究生国家奖学金

  2016年  博士生丁文玉获得研究生国家奖学金

社会任职:

 

研究方向:

  1. 神经干细胞与脑发育

  大脑新皮层,属于脑乃至整个神经系统进化上出现最晚,功能最复杂的部分,人类的大脑皮层与其他哺乳动物相比,结构上大而厚,且功能复杂。这些特点决定了人类独特的认知和创造能力。其中神经细胞数量的大量增加,是人类大脑皮层增大、厚的必要条件。我们关注神经干细胞及其亚型如何通过分裂、分化增加神经细胞的数量,从而增加脑容量。利用各种模式动物以及基因操作技术,我们将阐明大脑皮层增大、增厚的细胞与分子机制。

  2. 成体神经干细胞与微环境

  众所周知,在成年的哺乳动物的大脑中依然存在能够产生神经干细胞的区域,包括侧脑室的室管膜下区(SVZ)和海马齿状回颗粒下区(SGZ)。和胚胎期或者新生时期的发育不同,这些成体动物大脑中新生的颗粒细胞需要整合到形态和功能都已经发育成熟的微环境中(例如海马和嗅球)。而这一重塑过程不仅直接影响海马相关的学习和记忆功能,而且和许多神经精神疾病紧密相关,例如衰老引起的认知障碍、抑郁症和癫痫等。因此,系统阐明清楚成体新生神经元在整合到神经环路过程的形态和功能的微环境的因素显得尤为重要,这为利用神经干细胞的移植治疗中枢神经系统的损伤和神经退行性疾病提供新的治疗策略。

  3. 大脑皮层神经环路发育

  大脑皮层复杂的神经网络发育基础是大脑皮层发育的重要问题。神经干细胞通过分裂、分化和迁移,构成大脑新皮层的六层结构,伴随着皮层结构的形成,功能神经网络也逐渐形成。我们将利用过多光子活体时序影像技术和电生理技术,并结合生物化学,细胞生物学以及分子生物学,系统阐述大脑皮层神经网络发育的基本规律。

  4. 脑的细胞多样性与进化中的分子演化

  人类大脑皮层与低等的哺乳动物的大脑皮层相比,结构上大而厚并且有沟和回的结构。人类大脑皮层中各种细胞种类多样,包括神经元、胶质细胞等类型。仅仅就神经元来说也分为多种亚型。我们将利用单细胞测序技术,结合转基因动物等方法,分析和阐明人类大脑皮层细胞的多样性,以及这些细胞和组织结构的复杂性是如何在进化中从分子水平上进行调控的。

  5. 神经系统疾病

  神经系统疾病种类繁多,我们主要关注与大脑皮层发育、神经环路形成、以及和衰老相关的神经系统疾病。例如,头小畸形症、平滑脑症、抑郁症、孤独症、癫痫以及神经退行性疾病。目前实验室应用病人多能干细胞和已有多种疾病动物模型,对于神经系统疾病的发病机制开展细胞水平和分子水平的研究,为疾病的治疗提供理论基础和新的策略。

承担项目情况:

 

代表论著:

  1. Zhong S, Ding W, Sun L, Lu Y, Dong H, Fan X, Liu Z, Chen R, Zhang S, Ma Q, Tang F, Wu Q*, Wang X*. Decoding the development of human hippocampus. Nature. 2020; 577(7791): 531-536. (*Corresponding Author)

  2. Zhou X, Zhong S, Peng H, Liu J, Ding W, Sun L, Ma Q, Liu Z, Chen R, Wu Q, Wang X*. Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus. Nat Communications. 2020 Aug 13;11(1):4063. (*Corresponding Author)

  3. Shi Y, Sun L, Wang M, Liu J, Zhong S, Li R, Li P, Guo L, Fang A, Chen R, Ge WP, Wu Q*, Wang X*. Vascularized human cortical organoids (vOrganoid) model cortical development in vivo. Plos Biology. 2020; May 13;18(5). (*Corresponding Author)

  4. Lu Y, Shiau F, Yi W, Lu S, Wu Q, Pearson JD, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O'Brien GL, Sherman TD, Duan X, Fertig EJ, Goff LA, Zack DJ, Handa JT, Xue T*, Bremner R,*, Blackshaw S*, Wang X*, Clark BS*. Single-cell analysis of human retina identifies evolutionarily conserved and species specific mechanisms controlling development. Developmental Cell. 2020; May 18;53(4):473-491. (*Corresponding Author)

  5. Yin C, Zhou X, Wang W, Yao Y, Wu Q* and Wang X*. Abundant self-amplifying intermediate progenitors in the subventricular zone of the Chinese tree shrew neocortex. Cerebral Cortex. 2020 May 14;30(5):3370-3380. (*Corresponding Author)

  6. Yi W, Lu Y, Zhong S, Zhang M, Sun L, Dong H, Wang M, Wei M, Xie H, Qu H, Peng R, Hong J, Yao Z, Tong Y, Wang W, Ma Q, Liu Z, Ma Y, Li S, Yin C, Liu J, Ma C, Wang X*, Wu Q*, Xue T*. A single-cell transcriptome atlas of the aging human and macaque retina. National Science Review, 2020 August 25. nwaa179. (*Corresponding Author)

  7. Fan X, Fu Y, Zhou X, Sun L, Yang M, Wang M, Chen R, Wu Q, Yong J, Dong J, Wen L, Qiao J*, Wang X*, Tang F*. Single-cell transcriptome analysis reveals cell lineage specification in temporal spatial patterns in human cortical development. Science Advances, 2020 Aug 21;6(34):eaaz2978. doi: 10.1126/sciadv.aaz2978. (*Corresponding Author)

  8. Ding W, Zhang C, Wang B, Zhou X, Sun L, Zhong S, Liu J, Zhang J, Wang X*, Wu Q*. Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Sci China Life Sci. 2020 Aug 13. doi: 10.1007/s11427-020-1767-5. (*Corresponding Author)

  9. Sun L, Chen R, Li L, Yuan B, Song K, Pan N, Cheng T, Chang S, Lin K, He X, Wu Q, Xu F, Qiu Z*, Wang X*. Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice. Science Bulletin. 2020 July 30; 65(14):1192-1202. (*Corresponding Author)

  10. Liu J, Wang M, Sun L, Pan N, Zhang C, Zhang J, Zuo Z, He S, Wu Q*, Wang X*. Integrative Analysis of in Vivo Recording with Single-Cell RNA-seq Data Reveals Molecular Properties of Light-Sensitive Neurons in Mouse V1. Protein Cell. 2020 Jun; 11(6): 417-432. (*Corresponding Author)

  11. Pan N, Fang A, Shen C, Sun L, Wu Q and Wang X*. Early Excitatory Activity-dependent Maturation of Somatostatin Interneurons in Cortical Layer 2/3 of Mice. Cerebral Cortex. 2019 Sep 13;29(10):4107-4118. (Corresponding Author)

  12. Sun L*, Chen R, Bai Y, Li J, Wu Q*, Shen Q*, Wang X*. Morphological and Physiological Characteristics of Ebf2-EGFP-Expressing Cajal-Retzius Cells in Developing Mouse Neocortex. Cerebral Cortex. 2019 Sep. 29(9):3864-3878 (Corresponding Author)

  13. Ding W, Wu Q, Sun L, Pan NC, Wang X*. Cenpj regulates cilia disassembly and neurogenesis in the developing mouse cortex. Journal of Neuroscience. 2019 Mar 13;39(11):1994-2010. (*Corresponding Author)

  14. Tong DL, Chen RG, Lu YL, Li WK, Zhang YF, Lin JK, He LJ, Dang T, Shan SF, Xu XH, Zhang Y, Zhang C, Du YS, Zhou WH, Wang X*, Qiu Z*. The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice. Neurobiol Dis, 2019. 130: p. 104486. (*Corresponding Author)

  15. Xie H, Zhang W, Zhang M, Akhtar T, Li W, Sun X, Zuo Z, Wei W, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K, TianXue. Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids. Sci Adv. 2020;6(6):eaay5247.

  16. Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, Zhuang Z, Shi Y, Peng L, He R, Yang Y, Sun J, Wang X, Xu H, Zeng Z, Zou P, Lei X, Luo W, Li Y. MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife. 2019 Sep 10;8. pii: e48431. doi: 10.7554/eLife.48431.

  17. Yang Y, Chen R, Wu X, Zhao Y, Fan Y, Xiao Z, Han J, Sun L, Wang X, Dai J. Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules. Stem Cell Reports. 2019 Nov 12;13(5):862-876.

  18. Li A, Zalesky A, Yue W, Howes O, Yan H, Liu Y, Fan L, Whitaker KJ, Xu K, Rao G, Li J, Liu S, Wang M, Sun Y, Song M, Li P, Chen J, Chen Y, Wang H, Liu W, Li Z, Yang Y, Guo H, Wan P, Lv L, Lu L, Yan J, Song Y, Wang H, Zhang H, Wu H, Ning Y, Du Y, Cheng Y, Xu J, Xu X, Zhang D, Wang X, Jiang T, Liu B.A. Neuroimaging Biomarker for Striatal Dysfunction in Schizophrenia. Nature Medicine. 2020 Apr; 26(4):558-565.

  19. Du R., Zhu X., Wu S., Zhang X., He Y., Zhang K., He X., Wang X., Sun Y., Wang Q., Zhang H., and Tian M., PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. Eur J Nucl Med Mol Imaging, 2019. 46(11): p. 2392-2397.

  20. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J, Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell, 2019. 10(9): p. 649-667.

  21. Fan X, Dong J, Zhong S, Wei Y, Wu Q, Yan L, Yong J, Sun L, Wang X, Zhao Y, Wang W, Yan J, Wang X*, Qiao J*, Tang F*. Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis. Cell Res. 2018 Jul; 28(7):730-745. (*Corresponding Author)

  22. Zhong S, Zhang S, Fan X, Wu Q, Yan L, Dong J, Zhang H, Li L, Sun L, Pan N, Xu X, Tang F*, Zhang J*, Qiao J*, Wang X*. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. 2018 Mar 14. doi: 10.1038/nature25980. (*Corresponding Author)

  23. Shi Y, Li S, Wu Q, Sun L, Zhang J, Pan N, Wang Q, Bi Y, An J, Lu X, Gao GF*, Wang X*. Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring. Sci Rep. 2018 Feb 23;8(1):3541. (*Corresponding Author)

  24. Li R, Sun L, Fang A, Li P, Wu Q*, Wang X*. Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease. Protein Cell. 2017 Nov;8(11):823-833. (*Corresponding Author)

  25. Liu J, Liu W, Yang L, Wu Q, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J*, Tang F* and Wang X*. Primate-specific gene TMEM14B promotes cortical expansion and folding. Cell Stem Cell. 2017 Nov 2;21(5):635-649. (*Corresponding Author)

  26. Ju XC, Hou QQ, Sheng AL, Wu KY, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo ZG. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. Elife. 2016 Aug 9;5.

  27. Yuan Q, Deng KY, Sun L, Chi S, Yang Z, Wang J, Xin HB*, Wang X*, Ji G*. Calstabin 2: An important regulator for learning and memory in mice. Sci Rep. 2016 Feb 18; 6: 21087.(*Corresponding Author)

  28. Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S*, Wang X*. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nature Communications. 2016 Jan 22; 7:10481. (*Corresponding Author)

  29. Kou Z, Wu Q, Kou X, Yin C, Wang H, Zuo Z, Zhuo Y, Chen A, Gao S*, Wang X*. CRISPR/Cas9-mediated genome engineering of the ferret. Cell Res. 2015 Dec; 25(12): 1372-5. (*Corresponding Author)

  30. Zhao YG, Sun L, Miao G, Ji C, Zhao H, Sun H, Miao L, Yoshii SR, Mizushima N, Wang X, Zhang H. Autophagy. 2015; 11(6): 881-90.

  31. Gertz CC, Lui JH, LaMonica BE, Wang X, Kriegstein AR. Diverse behaviors of outer radial glia in developing ferret and human cortex. J Neurosci. 2014 Feb 12;34(7):2559-70.

  32. Wu Q, Liu J, Fang A, Li R, Bai Y, Kriegstein AR, Wang X. Chapter2: The Dynamics of Neuronal Migration, Cellular and Molecular Control of Neuronal Migration, 1st Edition, 2014, Springer, ISBN 978-94-007-7687-6.

  33. Wang X and KriegsteinA OSVZ Radial Glial Cells, Book Chapter, Neuroglia. 3rd Edition. Oxford University Press.

  34. Li R, Bai Y, Liu T, Wang X* and Wu Q*.Induced pluripotency and direct reprogramming: a new window for treatment of neurodegenerative diseases. Protein Cell. 2013 Jun; 4(6): 415-24. (*Corresponding Author)

  35. Lamonic B, Liu J, Wang X & Kriegstein A. An updated perspective on human neurodevelopmental disease. Current Opinion in Neurobiology. 2012 Oct; 22(5): 747-53. (Cover)

  36. Wu Q* and Wang X*. Neuronal stem cells in the central nervous system and in human diseases. Protein Cell. 2012 Apr; 3(4): 262-70. (*Corresponding Author)

  37. Wang X, Liu J & Kriegstein A. Orienting fate: spatial regulation of neurogenic divisions. Neuron. 2011 Oct. 20; 72(2): 191-3.

  38. Wang X*, Tsai JW, LaMonica B, Kriegstein AR. A new subtype of cortical progenitor cell in the mouse embryonic neocortex. Nat Neurosci, 14, 555-561 (2011) (Cover; featured in News and Views)(* Corresponding Author)

  39. Imai JH, Wang X, Shi SH. Kaede-Centrin1 Labeling of Mother and Daughter Centrosomes in Mammalian Neocortical Neural Progenitors. Curr Protoc Stem Cell Biol. 2010 Oct; Chapter 5:Unit 5.

  40. Wang X, Tsai JW, Imai JH, Lian WN, Vallee RB, Shi SH. Asymmetric segregation of mother and daughter centrosome in mammal neocortex. Nature. 2009 Oct 15; 461: 947-55. (Cover; Featured in News and Views).

  41. Yu YC, Bultje RS, Wang X, Shi SH Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature. 2009 Mar 26; 458: 501-4.

 

(资料来源:王晓群研究员,2020-09-30)