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姓氏首字母A-G

冯巍  博士 研究员 博士生导师  

中科院生物物理所,生物大分子国家重点实验室,研究组长

研究方向:细胞极性调控及细胞内货物运输的结构生物学研究

电子邮件:wfeng@ibp.ac.cn

电       话:010-64888751, 010-64888853

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_xsszmA_G/202005/t20200519_5583016.json

 

简       历:

  1997 - 2001 复旦大学化学系,化学学士

  2001 - 2005 香港科技大学生物化学系,生物化学博士

  2005 - 2007 香港科技大学生物化学系,博士后研究助理

  2007 - 2009 香港科技大学生物化学系,研究助理教授

  2009 - 至今 中科院生物物理研究所,研究员,博士生导师

获奖及荣誉:

 

社会任职:

 

研究方向:

  基于核磁共振和晶体衍射等技术方法,本研究组主要从事细胞极性调控及细胞内货物运输的结构生物学研究:

  1. 细胞极性调控相关蛋白质复合物的结构与功能研究

  细胞极性是细胞基本特性,对各类细胞生命活动有重要作用,譬如胚胎细胞的不对称分裂﹑上表皮细胞的生长﹑神经细胞的发育以及癌症细胞的迁移等。细胞极性的建立、维持及转换是一个非常复杂的过程,受到一系列蛋白质复合物的精密调控。这些蛋白质复合物非常保守,其在细胞内的特异性定位是细胞极性建立的关键步骤,并标志细胞极性的产生。我们主要对参与调控细胞极性的重要蛋白质复合物进行结构与功能研究,重点研究极性蛋白质复合物的组装及其介导极性调控信号通路的分子机制。通过研究,希望可以阐明细胞极性建立和维持的一些基本规律。

  2. 细胞内分子马达货物运输的结构机制研究

  细胞内定向货物运输是细胞完成各项生物功能所必需的基本活动,主要负责细胞内物质传递、交换和循环使用,定向货物运输的阻断和变异与众多重大生理疾病相关联。分子马达是连接细胞骨架和运输货物并提供直接动力能源的蛋白质分子,是细胞内定向运输系统的核心部分。我们主要对参与调控细胞内定向货物运输的分子马达进行结构与功能研究,重点研究分子马达运动调控(包括二聚化调控及活性调控等)的结构机制。通过研究,希望可以阐明分子马达的基本运动模式及其调控细胞内定向货物运输的一些基本规律。

承担项目情况:

 

代表论著:

  1. Ren, J., Liang, R., Wang, W., Zhang, D., Yu, L., and Feng, W.*, (2020). "Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy." Nat Commun. 11(1): 2702. (*: corresponding authors)

  2. Zhang, Z., Li, W., Yang, G., Lu, X., Qi, X., Wang, S., Cao, C., Zhang, P., Ren, J., Zhao, J., Zhang, J., Hong, S., Tan, Y., Burchfield, J., Yu, Y., Xu, T., Yao, X., James, D., Feng, W.*, and Chen, Z.*, (2020). "CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion." Cell Discov. 6(1): 92. (*: corresponding authors)

  3. Xu, Y., Ren, J., He, X., Chen, H., Wei, T.*, and Feng, W.*, (2019). "YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. " Autophagy 15(6): 1017-1030. (*: corresponding authors)

  4. Liang, R., Ren, J., Zhang, Y., and Feng, W.*, (2019). "Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins. " J Mol Biol 431 (7): 1494-1505.(*: corresponding authors)

  5. Ren, J., Wang, S., Chen, H., Wang, W., Huo, L., and Feng, W.*, (2018). "Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. " Proc Natl Acad Sci U S A 115(51): E11933-E11942 (*: corresponding authors)

  6. Ren, J., Zhang, Y., Wang, S., Huo, L., Lou, J., and Feng, W.*, (2018). "Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. " J Mol Biol 430(14):2030-2041. (*: corresponding authors)

  7. Yi, F., Kong, R., Ren, J., Zhu, L., Lou, J., Wu, J.Y., and Feng, W.*, (2016) "Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism" J Mol Biol. 428(15): 3043-57. (*: corresponding authors)

  8. Ren, J., Huo, L., Wang, W., Zhang, Y., Li, W., Lou, J., Xu, T., and Feng, W.*, (2016) "Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A" J Biol Chem. 291(7): 3581-94.(*: corresponding authors)

  9. Nie, S., Ke, H., Gao, F., Ren, J., Wang, M., Huo, L., Gong, W., and Feng, W.*, (2016) "Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators" Structure. 24(1): 80-91.(*: corresponding authors)

  10. Ren, J., Feng, L., Bai, Y., Pei, H., Yuan, Z., and Feng, W.*, (2015) "Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule" Biochem J. 468(1): 133-44.(*: corresponding authors)

  11. Kong, R., Yi, F., Wen, P., Liu, J., Chen, X., Ren, J., Li, X., Shang, Y., Nie, Y., Wu, K., Fan, D., Zhu, L.*, Feng, W.*, and Wu, J.Y.*, (2015) "Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression" J Clin Invest. 125(12): 4407-20.(*: corresponding authors)

  12. Zhang, Y., Wang, W., Chen, J., Zhang, K., Gao, F., Gao, B., Zhang, S., Dong, M., Besenbacher, F., Gong, W., Zhang, M., Sun, F.*, and Feng, W.*, (2013) "Structural insights into the intrinsic self-assembly of Par-3 N-terminal domain" Structure. 21(6): 997-1006.(*: corresponding authors)

  13. Wang, C., Li, W., Ren, J., Fang, J., Ke, H., Gong, W., Feng, W.*, and Wang, C.C.*, (2013) "Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase" Antioxid Redox Signal. 19(1): 36-45.(*: corresponding authors)

  14. Huo, L., Yue, Y., Ren, J., Yu, J., Liu, J., Yu, Y., Ye, F., Xu, T.*, Zhang, M.*, and Feng, W.*, (2012) "The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A" Structure. 20(9): 1550-61.(*: corresponding authors)

  15. Huo, L., Wen, W., Wang, R., Kam, C., Xia, J., Feng, W.*, and Zhang, M.*, (2011) "Cdc42-dependent formation of the ZO-1/MRCKb complex at the leading edge controls cell migration" EMBO J. 30(4): 665-78.(*: corresponding authors)

  16. Yu, C.#, Feng, W.#, Wei, Z., Miyanoiri, Y., Wen, W., Zhao, Y., and Zhang, M., (2009) "Myosin VI undergoes cargo-mediated dimerization" Cell. 138(3): 537-48. (#: co-first authors)

  17. Feng, W. and Zhang, M., (2009) "Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density" Nat Rev Neurosci. 10(2): 87-99.(invited review)

  18. Wu, H.#, Feng, W.#, Chen, J., Chan, L.N., Huang, S., and Zhang, M., (2007) "PDZ domains of Par-3 as potential phosphoinositide signaling integrators" Mol Cell. 28(5): 886-98. (#: co-first authors)

 

(资料来源:冯巍研究员,2020-12-28)