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生物大分子国家重点实验室

李梅  博士 研究员  

中科院生物物理所,生物大分子国家重点实验室,研究组长

研究方向:光合作用相关(膜)蛋白及复合物的结构与功能

电子邮件:meili@ibp.ac.cn

电       话:010-64888511

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_xsszmL/202005/t20200519_5583000.json

 

简       历:

  1991.09 - 1995.07 天津市南开大学,获理学学士学位

  1999.09 - 2002.07 中国科学院科院生物物理研究所,获理学硕士学位

  2004.09 - 2007.07 中国科学院科院生物物理研究所,获理学博士学位

  1995.07 - 1999.06 中科院生物物理所,研究实习员

  1999.07 - 2004.06 中科院生物物理所,助理研究员

  2007.07 - 2016.12 中科院生物物理所,副研究员

  2016.12 - 至今      中科院生物物理所,研究员

获奖及荣誉:

 

社会任职:

 

研究方向:

  光合作用是地球上最重要的化学反应之一,放氧光合生物利用太阳能,将二氧化碳转变为有机物,同时释放氧气,为地球上几乎全部生物提供物质能量来源。光合作用分为光反应和暗反应两个阶段。光反应是在光合生物的类囊体膜上进行的,由5个超大的膜蛋白复合物共同完成,光反应过程中产生的ATP和NADPH被后续的暗反应利用,最终生成碳水化合物。对光合作用机理及其调控机制的研究有望为解决当前面临的粮食、能源、环境等问题提供解决方案。

  现阶段的研究内容主要集中在以下三个方面:

  1. 光反应途径相关膜蛋白及复合物的结构与功能研究;

  2. 光合生物对其捕光及电子传递的调节机理;

  3. 光合作用暗反应中关键酶及其调控系统的结构与功能研究。

承担项目情况:

 

代表论著:

  1. Cao P, Pan X, Su X, Liu Z, Li M*. Assembly of eukaryotic photosystem II with diverse light-harvesting antennas. Curr Opin Struct Biol. 2020 Aug;63:49-57.

  2. Yu A1; Xie Y1; Pan X; Zhang H; Cao P; Su X; Chang W; Li M*. Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle. Plant Cell. 2020 May;32(5):1556-1573.

  3. Gao Y1; Zhang H1; Fan M; Jia C; Shi L; Pan X; Cao P; Zhao X; Chang W; Li M*, Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase, Nat Commun., 2020 Mar 23, 11:1525

  4. Cao P1; Cao D1; Si L; Su X; Tian L; Chang W; Liu Z; Zhang X*; Li M*, Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex, Nature Plants, 2020 Feb 10, 6:167~176

  5. Pan X1; Cao D1; Xie F1; Xu F1; Su X; Mi H; Zhang X*; Li M*, Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase, Nat Commun., 2020 Jan 30, 11(1):610

  6. Pan X; Cao P; Su X; Liu Z; Li M*, Structural analysis and comparison of light-harvesting complexes I and II, BBA-Bioenergetics. 2020 Apr 1, 1861(4): 148038.

  7. Su X1, Ma J1, Pan X1, Zhao X, Chang W, Liu Z, Zhang X*, Li M*. Antenna arrangement and energy transfer pathways of a green algal photosystem I-LHCI supercomplex. Nat Plants. 2019 2019 Mar 8; 5: 273~281

  8. Pan X1, Ma J1, Su X1, Cao P, Chang W, Liu Z, Zhang X*, Li M*. Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II. Science. 2018, 360(6393):1109-1113.

  9. Cao P, Su X, Pan X, Liu Z, Chang W, Li M*. Structure, assembly and energy transfer of plant photosystem II supercomplex. Biochim Biophys Acta Bioenerg. 2018, 1859(9):633-644.

  10. Su X1, Ma J1, Wei X1, Cao P1, Zhu D, Chang W, Liu Z*, Zhang X*, Li M*. Structure and assembly mechanism of plant C(2)S(2)M(2)-type PSII-LHCII supercomplex. Science. 2017, 357(6353):815-820.

  11. Wei X1, Su X1, Cao P, Liu X,Chang W, Li M*, Zhang X*, Liu Z*. Structure of spinach photosystem II-LHCII supercomplex at 3.2 Å resolution.Nature. 2016, 534(7605):69-74.

  12. Fan M1, Xiao Y1, Li M*, Chang W*. Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation. Molecular Plant. 2016 9(9):1349-52

  13. g> Fan M, Li M*, Liu Z, Cao P, Pan X, Zhang H, Zhao X, Zhang J, Chang W*. Crystal structures of the PsbS protein essential for photoprotection in plants. Nature Structural & Molecular Biology, 2015, 22(9):729-735.

  14. Cao P1, Xie Y1, Li M*, Pan X, Zhang H, Zhao X, Su X, Cheng T,Chang W*. Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese-Induced Conformational Change. Molecular Plant, 2015,8, 664–666.

  15. Jia C, Li M*, Li J, Zhang J, Zhang H, Cao P, Pan X, Lu X*, Chang W*. Structural insights into the catalytic mechanism of aldehyde-deformylatingOxygenases. Protein Cell, 2015, 6(1):55–67.

  16. Zhang H, Li M*, Gao Y, Jia C, Pan X, Cao P, Zhao X, Zhang J, Chang W*. Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation. Protein Cell. 2015 Feb;6(2):147-51.

  17. Wan T, Li M*, Zhao X, Zhang J, Liu Z, Chang W*. Crystal structure of a multilayer packed major light-harvesting complex: implications for grana stacking in higher plants. Molecular Plant. 2014 May;7(5):916-9.

 

(资料来源:李梅研究员,2020-11-09)