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卜鹏程  博士 研究员 博士生导师  

中科院生物物理所,中国科学院核酸生物学重点实验室,研究组长

研究方向:非编码RNA与疾病,肿瘤及代谢

电子邮件:bupc@ibp.ac.cn

电       话:010-64889588

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/faculty/index_18316.html?json=http://www.ibp.cas.cn/sourcedb_ibp_cas/cn/ibpexport/EN_xsszmA_G/202005/t20200519_5583024.json

 

简       历:

  1997 - 2001  大连工业大学,工学学士 

  2001 - 2004  大连理工大学,工学硕士

  2004 - 2007  中科院生物物理研究所,理学博士

  2008 - 2010  美国加州大学伯克利分校,博士后

  2010 - 2015  美国康奈尔大学,研究助理

  2015 - 2016  美国杜克大学,资深科学家

  2017 - 至今  中科院生物物理研究所,研究员

获奖及荣誉:

 

社会任职:

 

研究方向:

  1. 非编码RNA在人类重大疾病中的功能和作用机制

  一系列重大疾病,尤其是肿瘤的发生发展与非编码RNA调控失衡相关。我们将致力于研究非编码RNA在人类重大疾病中的功能及其作用机制,尤其着重于研究非编码RNA对肿瘤发生、转移,细胞命运和细胞代谢的影响。

  2. 细胞代谢对肿瘤发生、转移及干细胞命运的影响

  细胞代谢为细胞提供其生长所需能量和生物合成的原料。理解细胞在在不同生理和病理条件下的代谢机理,进而改变其代谢途径是疾病治疗的新靶点。课题组将结合代谢组学,转录组学和小鼠模型研究细胞代谢对肿瘤的发生、转移,干细胞分裂、更新和分化的影响。

  3. 基于类器官培养的疾病靶基因鉴定和药物筛选

  类器官(Organoids)是由干细胞在体外3D培养,形成从细胞组成和结构上能够模拟体内相应器官的培养体,是研究器官发育、肿瘤生成和个性化精准治疗的重要工具。将利用建立并利用类器官培养库鉴定疾病相关基因和筛选个性化药物。

承担项目情况:

 

代表论著:

  1. Wang L, Wang E, Wang Y, Mines R, Xiang K, Sun Z, Zhou G, Chen KY, Rakhilin N, Chao S, Ye G, Wu Z, Yan H, Shen H, Everitt J, Bu P#, Shen X#. miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis. Elife. 2018;7. pii: e39479. doi: 10.7554/eLife.39479.

  2. Bu P*#, Chen KY*, Xiang K*, Johnson C*, Crown SB, Rakhilin N, Ai Y, Wang L, Xi R, Astapova I, Han Y, Li J, Barth BB, Lu M, Gao Z, Mines R, Zhang L, Herman M, Hsu D, Zhang GF, Shen X#. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab. 2018 27(6):1249-1262

  3. Yan H, Bu P#. Non-coding RNAs in cancer stem cells. Cancer Lett. 2018; 421:121-126.

  4. Chen KY, Srinivasan T, Tung KL, Belmonte JM, Wang L, Murthy PKL, Choi J, Rakhilin N, King S, Varanko AK, Witherspoon M, Nishimura N, Glazier JA, Lipkin SM, Bu P#, Shen X#. A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol. 2017 13(4):927.

  5. Bu P*#, Wang L*, Chen KY, Srinivasan T, Murthy PK, Tung KL, Varanko AK, Chen HJ, Ai Y, King S, Lipkin SM, Shen X#. miR-34a and Numb synergize for asymmetric cell fate determination to control stem cell proliferation. Cell Stem Cell. 2016 18(2):189-202.

  Highlighted in Cancer Discovery and AAAS

  6. Wang L*, Bu P*, Ai Y, Srinivasan T, Chen HJ, Xiang K, Lipkin SM, Shen X#. A large non-coding RNA regulates colon cancer stem cell asymmetric division. Elife. 2016; 10.7554/eLife.14620.

  7. Chen HJ*, Wei Z*, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA#, Shuler ML#. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016, 34(8):845-51.

  8. Srinivasan T, Walters J, Bu P, Than EB, Tung KL, Chen KY, Panarelli N, Milsom J, Augenlicht L, Lipkin SM#, Shen X#. Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells. Cancer Res. 2016; DOI: 10.1158/0008-5472.CAN-15-3198.

  9. Bu P*, Wang L*, Chen KY, Rakhilin N, Sun J, Closa A, Tung KL, King S, Kristine Varanko A, Xu Y, Huan Chen J, Zessin AS, Shealy J, Cummings B, Hsu D, Lipkin SM, Moreno V, Gümü? ZH, Shen X#. miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF- . Nat commun. 2015 6:6879.

  10. Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L#. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015, 17(12):1546-55

  11. Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, Wun B, Roy S, Shen X, King MR#. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2015 Oct 21;76:52-65

  12. Chen HJ, Sun J, Huang Z, Hou H Jr, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümü? ZH, Shuler M, Nishimura N, Edelmann W, Shen X#, Lipkin SM#. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer. Nat Biotechnol. 2015, 33(6):656-60.

  13. Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, He L#. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 2014 28: 438-450

  14. Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, Li J, Yang H, Milsom J, Lee S, Zipfel W, Jin MM, Gümü? ZH, Lipkin SM#, Shen X#. A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell. 2013, 12(5):602-625.

  Highlighted in Cell Stem Cell and Biotechniques.

  15. Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, Edelmann W, Gümüs ZH, Shen X#, Lipkin S#. The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis. J Clin Invest. 2012, 122(9):3184-96

  16. Choi YJ*, Lin CP*, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks GG, Hannon GJ, He L#. miR-34a miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011, 13(11):1353-60.

  17. Bu P, Zhuang J, Feng J, Yang D, Shen X, Yan X#. Visualization of CD146 dimerization and its regulation in living cells. BBA-Mol Cell Res. 2007, 1773(4):513-20.

  18. Bu P, Gao L, Zhuang J, Feng J, Yang D, Yan X#. Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation. Mol Cancer Ther. 2006, 5(11): 2872-2878

 

(资料来源:卜鹏程研究员,2020-05-07)