王东鹏----中国科学院生物物理研究所

王东鹏　/　博士研究员博士生导师

中国科学院生物物理研究所，表观遗传调控与干预全国重点实验室，研究组长

研究方向：DNA损伤修复、表观遗传学

电子邮件：wangd@ibp.ac.cn

电　　话：010-64888570

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmW/202409/t20240911_689302.html

基本情况研究方向代表成果人才培养团队风采

简历

2010 - 2014 湖北大学，学士

2014 - 2019 中国科学院大学，非编码RNA与染色质调控，博士

2020 - 2024 美国国立卫生研究院国家癌症研究所（National Cancer Institute,NIH），博士后

2024 - 至今中国科学院生物物理研究所，研究员，博士生导师

获奖及荣誉

社会任职

承担项目情况

　　DNA 损伤会引起基因组不稳定，诱发损伤修复，激活一系列细胞信号通路决定细胞命运：修复，凋亡或衰老。基因组不稳定性也被认为神经退行性疾病，癌症和免疫炎症的重要特征之一。

　　本课题组聚焦DNA损伤修复和表观遗传调控之间的互作及其对基因表达和细胞命运的作用是一个新颖而又关键的问题。主要研究内容包括：

1. DNA损伤在神经系统分化发育、可塑性及神经退行性疾病中的作用机制

　　神经元存在着极高水平的DNA单链损伤（single strand breaks,SSBs）和大量的双链损伤（double strand breaks,DSBs），本课题组通过各种生化分子，基因编辑和课题组已开发的检测DNA断裂和修复过程的高通量测序技术等手段，解析DNA损伤修复在神经系统分化发育及神经退行性疾病中的机制和功能。

2. DNA损伤与炎症及记忆形成

　　研究炎症与记忆形成的分子机制对于深入理解细胞衰老和神经退行性疾病至关重要，近期的研究表明DNA损伤与表观遗传修饰改变可能是炎症及记忆形成的重要事件，因此阐明DNA损伤与表观遗传调控在上述过程中的功能机制是本课题组的重点关注方向。

3. 非编码RNA及其他表观遗传因子对DNA损伤修复的作用

　　DNA损伤修复通路会受到表观遗传的精细调控，从而维持基因组的稳定性和DNA复制的准确性，我们将利用多组学研究技术研究非编码RNA及其他表观遗传因子在DNA修复过程中的功能机制，寻找其中重要的新分子靶点。

1. Jia-Cheng Liu^#, Dongpeng Wang^#, Elsa Callen, Chuanyuan Chen, Santiago Noriega, Yafang Shang, David Schürmann, Yawei Song, Gokul N. Ramadoss, Raj Chari, Nancy Wong, Yongge Zhao, Yuan He, Peter Aplan, Michael E. Ward, Nathaniel Heintz, Anjana Rao, Peter J. McKinnon, Keith Caldecott, Primo Schär, Fei-Long Meng, Ferenc Livak, Wei Wu, Andre Nussenzweig* Mechanism of cytarabine-induced neurotoxicity. Nature. 2025 (Accepted in principle)

2. Lihui Liu^#; Ziyang Liu^#; Qinghua Liu^#; Wei Wu^#; Peng Lin^#; Xing Liu^#; Yuechuan Zhang; Dongpeng Wang; Briana C. Prager; Ryan C. Gimple; Jichuan Yu; Weixi Zhao; Qiulian Wu; Wei Zhang; Erzhong Wu; Xiaomin Chen; Jianjun Luo; Jeremy N. Rich*; Qi Xie*; Tao Jiang*; Runsheng Chen*; LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O methylation. Nature Communications, 2023,14(1)

3. Dongpeng Wang^#; Wei Wu^#; Elsa Callen^#; Raphael Pavani; Nicholas Zolnerowich; Srikanth Kodali; Dali Zong; Nancy Wong; Santiago Noriega; William J. Nathan; Gabriel Matos-Rodrigues; Raj Chari; Michael J. Kruhlak; Ferenc Livak; Michael Ward; Keith Caldecott; Bruno Di Stefano; André Nussenzweig*; Active DNA demethylation promotes cell fate specification and the DNA damage response. Science, 2022, 378(6623):983-989. （Highlighted by Science 'Perspectives'; Recommended by Nature reviews molecular cell biology, Nature structural & molecular biology and Cancer discovery）

4. Chong Zhang^#; Dongpeng Wang^#; Yajing Hao^#; Shuheng Wu; Jianjun Luo; Yuanchao Xue; Di Wang; Guohong Li; Lihui Liu; Changwei Shao; Huiyan Li; Jinfeng Yuan; Maoxiang Zhu; Xiang-Dong Fu*; Xiao Yang*; Runsheng Chen*; Yan Teng*; LncRNA CCTT-mediated RNA-DNA and RNA-protein interactionsfacilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly. Molecular Cell, 2022, 82(21):4018-4032.e9

5. Xiaoli Cui; Ruijin Zhang; Ye Yang; Erzhong Wu; Yiheng Tang; Zhihua Zhao; Chao Li; Lei Yang; Xueyi Teng; Yanzhen Ye; Ya Cui; Feng Xu; Zewen Su; Dongpeng Wang; Dongdong Zhang; Yan Yang; Jianyuan Sun; Jianjun Luo*; Shuli Zhang*; Runsheng Chen*; Jianzhong Jeff Xi*; Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory. Cell Reports, 2022, 38(8):110398

6. Wei Wu^#; Sarah E. Hill^#; William J. Nathan^#; Jacob Paiano; Elsa Callen; Dongpeng Wang; Kenta Shinoda; Niek van Wietmarschen; Jennifer M. Colón-Mercado; Dali Zong; Raffaella De Pace; Han-Yu Shih; Steve Coon; Maia Parsadanian; Raphael Pavani; Hana Hanzlikova; Solji Park; Seol Kyoung Jung; Peter J. McHugh; Andres Canela; Chongyi Chen; Rafael Casellas; Keith W. Caldecott*; Michael E. Ward*; André Nussenzweig*; Neuronal enhancers are hotspots for DNA single-strand break repair. Nature, 2021, 593(7859):440-444

7. Yajing Hao^#; Dongpeng Wang^#; Shuheng Wu; Xiao Li; Changwei Shao; Peng Zhang; Jia-Yu Chen; DoHwan Lim; XiangDong Fu*; Runsheng Chen*; Shunmin He*; Active retrotransposons help maintain pericentromeric heterochromatin required for faithful cell division. Genome Research, 2020, 30(11):1570-1582

8. Shuheng Wu^#; Erzhong Wu^#; Dongpeng Wang^#; Yiwei Niu; Haiyan Yue; Dongdong Zhang; Jianjun Luo*; Runsheng Chen*; LncRNA HRCEG,regulated by HDAC1,inhibits cells proliferation and epithelial mesenchymal-transition in gastric cancer. Cancer genetics, 2020, 241: 25-33

9. Yanying Wang; Pingping Zhu; Jianjun Luo; Jing Wang; Zhiwei Liu; Wei Wu; Ying Du; Buqing Ye; Dongpeng Wang; Lei He; Weizheng Ren; Jianyi Wang; Xianhui Sun; Runsheng Chen*; Yong Tian*; Zusen Fan*; LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling. EMBO Journal, 2019, 38(17):e101110-e101110

10. Ya Cui ^#; Xiaowei Chen^#; Yiwei Niu ^#; Dongpeng Wang; Huaxia Luo; Zhen Fan; Dan Wang; Wei Wu; Xueyi Teng; Shunmin He; Jianjun Luo; Runsheng Chen*; Dynamic-BM: multispecies Dynamic BodyMap database from temporal RNA-seq data. BRIEFINGS INBIOINFORMATICS, 2018, 6(19):1302-1309

11. Bao Zhang^#; Dongpeng Wang^#; Jing Wu^#; Jun Tang; Weixiong Chen; Xiaomin Chen; Dongdong Zhang; Yanming Deng; Mingzhou Guo; Yuejian Wang*; Jianjun Luo*; Runsheng Chen*; Expression Profiling and Functional Prediction of Long Noncoding RNAs in Nasopharyngeal Nonkeratinizing Carcinoma. DISCOVERYMEDICINE, 2016, 116(21):239-250

（资料来源：王东鹏研究员，2025-05-26）

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