邓红雨----中国科学院生物物理研究所

邓红雨　/　博士研究员博士生导师

国家“杰出青年科学基金”获得者
中国科学院生物物理研究所，生物大分子全国重点实验室，研究组长

研究方向：病毒复制和组装释放的分子机理；病毒与天然免疫系统的互作；新型疫苗的研发

电子邮件：hydeng@ibp.ac.cn

电　　话：010-64888407

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmA_G/202005/t20200519_341421.html

基本情况研究方向代表成果人才培养团队风采

简历

1987 - 1991 浙江大学，生物科学与技术系，理学士

1992 - 1997 美国罗彻斯特大学，博士

1998 - 2002 爱因斯坦医学院及加州大学洛杉矶分校，博士后

2002 - 2004 加州大学洛杉矶分校，助理研究员及助理教授

2004 - 至今中国科学院生物物理研究所，研究员

获奖及荣誉

社会任职

承担项目情况

　　邓红雨研究组长期的研究方向是病毒复制及组装释放的分子机理、病毒与宿主天然免疫系统之间的相互作用以及新型疫苗的研发。截至目前已在Science Advances，Molecular Cell，PNAS，Journal of Virology，Nature Communications,Journal of Cell Biology等国际著名期刊发表论文70余篇。

　　研究表明约15-20%的人类癌症在病因学上与病毒感染有关。邓红雨研究组长期的研究重点是疱疹病毒γ亚家族的成员，包括Epstein-Barr病毒（EBV）和Kaposi's肉瘤相关疱疹病毒（KSHV），这两种病毒与肿瘤的发生发展密切相关，可引起鼻咽癌和恶性淋巴瘤等。以往的研究大都关注于病毒潜伏期表达的致瘤基因，而近期临床和基础研究结果都表明，裂解期复制对病毒致瘤亦至关重要。由于EBV和KSHV难以在体外进行高滴度培养并且缺乏理想的小动物模型，对其裂解期复制的研究受到了限制。邓红雨研究组同时采用了在分子水平上与EBV以及KSHV高度同源的鼠疱疹病毒68（MHV-68）为实验模型，研究致瘤疱疹病毒的组装释放以及病毒与宿主相互作用的机理。通过长期积累，已建立了一套较完整的体系，在分子、细胞和动物水平上深入系统地研究致瘤性疱疹病毒复制的关键步骤、调控机理及与宿主的相互作用。

　　目前主要研究方向如下：

　　1. 致瘤病毒复制和组装释放的分子机理

　　2. 病毒与天然免疫系统间的相互作用

　　3. 新型疫苗的研发

代表论著(*：通讯作者)

1. Tian H,Yu K,He L,Xu H,Han C,Zhang X,Wang X,Zhang X,Zhang L,Gao G,Deng H*. RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription Activator. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2218825120. doi: 10.1073/pnas.2218825120.

2. Ji M^#,Li M^#,Sun L^#,Deng H*,Zhao YG*. DMV biogenesis during β-coronavirus infection requires autophagy proteins VMP1 andTMEM41B. Autophagy. 2023 Feb;19(2):737-738. doi: 10.1080/15548627.2022.2103783.

3. Zhou S,Fu Z,Zhang Z,Jia X,Xu G,Sun L,Sun F,Gao P,Xu P,Deng H*. Liquid-liquid phase separation mediates the formation of herpesvirus assembly compartments. J Cell Biol. 2023 Jan 2;222(1):e202201088. doi: 10.1083/jcb.202201088. Epub 2022 Oct 17.

4. Jia X^#,Sun L^#,Shen S,Zhang Z,Lyu Y,Guo H,Deng H*. The Interaction between Tegument Proteins ORF33 and ORF45 Plays an Essential Role in Cytoplasmic Virion Maturation of a Gammaherpesvirus. J Virol. 2022 Nov 23;96(22):e0107322. doi: 10.1128/jvi.01073-22. Epub 2022 Oct 27.

5. Gao X^#,Tian H^#,Zhu K^#,Li Q,Hao W,Wang L,Qin B,Deng H*,Cui,S*. Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport. Nat Commun. 2022 Aug 15;13(1):4782. doi: 10.1038/s41467-022-32489-5.

6. Ji M^#,Li M^#,Sun L^#,Zhao H,Li Y,Zhou L,Yang Z,Zhao X,Qu W,Xue H,Zheng Z,Li Y,Deng H*,Zhao YG*. VMP1 andTMEM41Bare essential for DMV formation during β-coronavirus infection. J Cell Biol. 2022 Jun 6;221(6):e202112081. doi: 10.1083/jcb.202112081.

7. Guo C^#,Peng Y^#,Lin L^#,Pan X^#,Fang M^#,Zhao Y,Bao K,Li R,Han J,Chen J,Song TZ,Feng XL,Zhou Y,Zhao G,Zhang L,Zheng Y,Zhu P,Hang H,Zhang L,Hua Z*,Deng H*,Hou B*. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates. Cell Rep Med. 2021 Nov 16;2(11):100448.

8. Xu G^#,Liu C^#,Zhou S^#,Li Q,Feng Y,Sun P,Feng H,Gao Y,Zhu J,Luo X,Zhan Q,Liu S,Zhu S,Deng H*,Li D*,Gao P*. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Mol Cell. 2021 Jul 1;81(13):2823-2837.e9.

9. Yu K,Tian H,Deng H*. PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion. Sci Adv. 2020 Nov 20;6(47):eabd0276.

10. Feng H^#,Tian H^#,Wang Y,Zhang Q,Lin N,Liu S,Yu Y,Deng H*,Gao P*. Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10. Proc Natl Acad Sci USA. 2020 Oct 27;117(43):26719-26727.

11. Lv Y^#,Shen S^#,Xiang L,Jia X,Hou Y,Wang D,Deng H*. Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus. J Virol. 2019 Nov 26;93(24):e01422-19.

12. Lv Y,Zhou S,Gao S,Deng H*. Remodeling of host membranes during herpesvirus assembly and egress. Protein Cell. 2019 May;10(5):315-326.

13. Gong D,Dai X,Xiao Y,Du Y,Chapa TJ,Johnson JR,Li X,Krogan NJ,Deng H,Wu TT,Sun R*. Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling. J Virol. 2017 Jul 12;91(15). e00362-17.

14. Jia X^#,Shen S^#,Lv Y,Zhang Z,Guo H,Deng H*. Tegument Protein ORF45 Plays an Essential Role in Virion Morphogenesis of Murine Gammaherpesvirus 68. J Virol. 2016 Jul 27;90(16):7587-92.

15. Chen Y,He L,Shi X,Chen J,Zhong J,Chen X,Cheng G*,Deng H*. The hepatitis C virus protein NS3 suppresses TNF-a-stimulated activation of NF-kB by targeting LUBAC. Sci Signal. 2015 Nov 17;8(403):ra118.

16. Qi J^#,Han C^#,Gong D^#,Liu P,Zhou S,and Deng H*. Murine gammaherpesvirus 68 ORF48 is an RTA responsive gene product and functions in both viral lytic replication and latency during in vivo infection. J Virol. 2015 Jun 1;89(11):5788-800.

17. Shen S,Jia X,Guo H,and Deng H*. Gammaherpesvirus Tegument Protein ORF33 Is Associated with Intranuclear Capsids at an Early Stage of the Tegumentation Process. J Virol. 2015 May;89(10):5288-97.

18. Chen Y,Wang S,Yi Z,Tian H,Aliyari S,Li Y,Chen G,Liu P,Zhong J,Chen X,Du P,Su L,Qin FX,Deng H*,Cheng G*. Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms. Sci Rep. 2014 Dec 3;4:7242.

19. Shen S,Guo H,and Deng H*. Murine gammaherpesvirus-68 ORF38 encodes a tegument protein and is packaged into virions during secondary envelopment. Protein Cell. 2014 Feb;5(2):141-50.

20. Xuan Y,Gong D,Qi J,Han C,Deng H*,Gao G*. ZAP inhibits murine gammaherpesvirus 68 ORF64 expression and is antagonized by RTA. J Virol. 2013 Mar;87(5):2735-43.

21. Xuan Y,Liu L,Shen S,Deng H*,Gao G*. Zinc-finger antiviral protein inhibits murine gammaherpesvirus-68 M2 expression and regulates viral latency in cultured cells. J Virol. 2012 Nov;86(22):12431-4.

22. Wang L,Guo H,Reyes N,Lee S,Bortz E,Guo F,Sun R,Tong L,Deng H*. Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment. J Virol. 2012 Feb;86(3):1348-57.

23. Hong Y^#,Qi J^#,Gong D,Han C,Deng H*. Replication and Transcription Activator (RTA) of Murine Gammaherpesvirus-68 Binds to An RTA-responsive Element and Activates the Expression of ORF18. J Virol. 2011 Nov;85(21):11338-50.

24. Lee S^#,Salwinski L^#,Zhang C,Chu D,Sampankanpanich C,Reyes NA,Vangeloff A,Xing F,Li X,Wu T,Sahasrabudhe S,Deng H,LaCount DJ*,Sun R*. An Integrated Approach to Elucidate the Intra-Viral and Viral-Cellular Protein Interaction Networks of a Gamma-Herpesvirus. PLoS Pathog. 2011 Oct;7(10):e1002297.

25. Qi J,Gong D,and Deng H*. CCAAT/enhancer binding proteins play a role in oriLyt dependent genome replication during MHV-68 de novo infection. Protein Cell. 2011 Jun;2(6):463-9.

26. Ding X^#,Yang W^#,Shi X,Du P,Su L,Qin Z*,Chen J*,and Deng H*. TNF Receptor 1 Mediates Dendritic Cell Maturation and CD8 T Cell Response through Two Distinct Mechanisms. J Immunol. 2011 Aug 1;187(3):1184-91.

27. Hong Y,Qi J,Gong D,Deng J,Deng H*. Identification of an RTA Responsive Element in Murine Gammaherpesvirus-68 Genome. Progress in Biochemistry and Biophysics. 2011;38(10):936-944.

28. Yang W^#,Ding X^#,Deng J^#,Lu Y,Matsuda Z,Thiel A,Chen J,Deng H*,Qin Z*. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection. J Mol Med. 2011 Apr;89(4):399-409.

2010年以前代表性论著

1. Guo H,Shen S,Wang L,Deng H*. Role of tegument proteins in herpesvirus assembly and egress. Protein Cell. 2010 Nov;1(11):987-98. (Invited review).

2. Guo H,Wang LL,Peng L,Zhou ZH,and Deng H*. Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. J Virol. 2009 Oct;83(20):10582-95.

3. Liao HI^#,Olson CA^#,Hwang S,Deng H,Wong E,Baric RS,Roberts RW,Sun R*. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. J Biol Chem. 2009 Jun 26;284(26):17512-20.

4. Gong D,Qi J,Arumugaswami V,Sun R,Deng H*. Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus-68. Virology. 2009 May 10;387(2):285-95.

5. Yang Z,Tang H,Huang H,Deng H*. RTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivation. PloS One. 2009 4(2):e4556.

6. Lee S,Deng H*,Yu F,Melega WP,Damoiseaux R,Bradley KA,Sun R*. Regulation of Kaposi's sarcoma-associated herpesvirus Reactivation by Dopamine Receptor-Mediated Signaling Pathways. J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):531-40.

7. Benach J,Wang L,Chen Y,Ho CK,Lee S,Seetharaman J,Xiao R,Acton TB,Montelione GT,Deng H,Sun R*,Tong L*. Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus-68. J Biol Chem. 2007 Oct 26;282(43):31534-41. Epub 2007 Aug 15.

8. Bortz E,Wang L,Jia Q,Wu TT,Whitelegge JP,Deng H,Zhou ZH,Sun R*. Murine Gammaherpesvirus 68 ORF52 Encodes a Tegument Protein Required for Virion Morphogenesis in the Cytoplasm. J Virol. 2007 Sep;81(18):10137-50.

9. Deng H,Liang Y,Sun R. Regulation of KSHV lytic gene expression. Curr Top Microbiol Immunol. 2007;312:157-83. (Invited review).

10. Deng H*,Chu JT,Park NH,Sun R. Identification of cis-sequences required for lytic DNA replication and packaging of murine gammaherpesvirus 68. J Virol. 2004 Sep;78(17):9123-31.

11. Zhu J,Trang P,Kim K,Zhou T,Deng H,Liu F*. Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P. Proc Natl Acad Sci USA. 2004 Jun 15;101(24):9073-8. Epub 2004 Jun 7.

12. Deng H,Song MJ,Chu JT,Sun R*.Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). J Virol. 2002 Aug;76(16):8252-64.

13. Deng H,Chu JT,Rettig MB,Martinez-Maza O,Sun R*. Rta of the human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. Blood. 2002 Sep 1;100(5):1919-21.

14. Varthakavi V,Smith RM,Deng H,Sun R,Spearman P*. Human Immunodeficiency Virus Type-1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus through Induction of KSHV Rta. Virology. 2002 Jun 5;297(2):270-80.

15. Deng H,Young A,Sun R*. Auto-activation of the rta gene of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. J Gen Virol. 2000 Dec;81(Pt 12):3043-8.

16. Greenberg RA,O'Hagan RC,Deng H,Xiao Q,Hann SR,Adams RR,Lichtsteiner S,Chin L,Morin GB,DePinho RA*. Telomerase reverse transcriptase is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 1999 Feb 4;18(5):1219-26.

17. Deng H,Dewhurst S*. Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. J Virol. 1998 Jan;72(1):320-9.

18. Secchiero P,Nicholas J,Deng H,Xiaopeng T,van Loon N,Ruvolo VR,Berneman ZN,Reitz MS Jr,Dewhurst S*. Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity. J Virol. 1995 Dec;69(12):8041-5.

图书

1.《实验室生物安全》，2010，高等教育出版社。"十一五"国家重点图书。主要编委之一。

2.《中华医学百科全书-医学微生物学卷》，国家重点出版工程。负责编写疱疹病毒科条目的唯一编委。

3.《医学病毒学原理》，2020，化学工业出版社。第十五章，疱疹病毒。

（资料来源：邓红雨研究员，2024-09-14）

在职职工

田华彬，副研究员

本科毕业于河北农业大学，硕士毕业于中国农业科学院，他于2017年获得中国科学院生物物理研究所博士学位。目前是邓红雨课题组的副研究员，专注于病毒与天然免疫系统间的相互作用。
刘淑君，高级实验师

本科毕业于河北大学，硕士毕业于山东大学。她于2015年加入邓老师的实验室，目前是邓红雨课题组的高级实验师，主要负责课题组的日常管理及科研支撑等工作。
彭亚男，助理研究员

本科和硕士都毕业于山西大学，她于2018年获得中国科学院生物物理研究所博士学位。目前是邓红雨课题组的助理研究员，专注于新型疫苗的研发。