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现在位置:首页 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
Architecture of African swine fever virus and implications for viral assembly,Science, 17 Oct 2019
2019-10-17 | 【     】【打印】【关闭

Science17 October, 2019,DOI:https://doi.org/10.1126/science.aaz1439

Architecture of African swine fever virus and implications for viral assembly

Nan Wang*, Dongming Zhao*, Jialing Wang*, Yangling Zhang*, Ming Wang, Yan Gao, Fang Li, Jingfei Wang, Zhigao Bu, Zihe Rao, Xiangxi Wang

Abstract

African swine fever virus (ASFV) is a giant and complex DNA virus that causes a highly contagious and often lethal swine disease without vaccine available. Using an optimized image reconstruction strategy, we solved the ASFV capsid structure up to 4.1-angstroms, which is built from 17,280 proteins, including one major (p72) and four minor capsid proteins (M1249L, p17, p49 and H240R), organized into pentasymmetrons and trisymmetrons. The atomic structure of the p72 informs putative conformational epitopes, distinguishing ASFV from other nucleocytoplasmic large DNA viruses (NCLDV). The minor capsid proteins form a complicated network below the outer capsid shell, stabilizing the capsid by holding adjacent capsomers together. Acting as core organizers, 100-nm long M1249L proteins run along each edge of trisymmetrons bridging two neighboring pentasymmtrons and form extensive intermolecular networks with other capsid proteins, driving the formation of the capsid framework. These structural details unveil the basis of capsid stability and assembly, opening up new avenues for ASF vaccine development.

文章链接:https://science.sciencemag.org/content/early/2019/10/16/science.aaz1439.full

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201910/t20191016_5408830.html

 

 

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