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Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component, Nat Commun, 10 Sep 2018
2018-09-12 | 【     】【打印】【关闭

Nat Commun, 10 Sep 2018

Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component

Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu*, Xinzheng Zhang*, Zihe Rao* & Xiangxi Wang*

Abstract

Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae subfamily that together with the β- and γ-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 angstrom using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify α-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability.

文章链接:https://www.nature.com/articles/s41467-018-06078-4

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201809/t20180911_5076757.html

 

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