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In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy, Nat Commun, Epub 12 Apr 2018
2018-04-13 | 【     】【打印】【关闭

Nat Commun,Epub 12 Apr 2018,DOI: 10.1038/s41467-018-03903-8

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang, Xiyun Yan & Lizeng Gao

Abstract

Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as artificial enzymes in biomedicine. However, how to control their in vivo performance in a target cell is still challenging. Here we report a strategy to coordinate nanozymes to target tumor cells and selectively perform their activity to destruct tumors. We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive oxygen species regulation. We then introduce ferritin to guide nitrogen-doped porous carbon nanospheres into lysosomes and boost reactive oxygen species generation in a tumor-specific manner, resulting in significant tumor regression in human tumor xenograft mice models. Together, our study provides evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanozymes to target tumor cells for in vivo tumor catalytic therapy.

文章链接:https://www.nature.com/articles/s41467-018-03903-8

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201804/t20180413_4996449.html

 

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