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现在位置:首页 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
Drosophila FIT is a protein-specific satiety hormone essential for feeding control, Nature Communications, Published online:19 January 2017
2017-03-15 | 【     】【打印】【关闭

Nature Communications 8, Article number: 14161 (2017), Published online:19 January 2017,doi:10.1038/ncomms14161

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

Jinghan Sun, Chang Liu, Xiaobing Bai, Xiaoting Li, Jingyun Li, Zhiping Zhang, Yunpeng Zhang, Jing Guo & Yan Li

Abstract

Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph conveys this metabolic message to the brain, thereby promoting the release of Drosophila insulin-like peptide 2 (DILP2) and suppressing further protein intake. Interestingly, Fit is a sexually dimorphic gene, and consequently protein consumption-induced insulin release, as well as protein feeding behaviour, are also dimorphic between sexes. Thus, our findings reveal a protein-specific satiety hormone, providing important insights into the complex regulation of feeding decision, as well as the sexual dimorphism in feeding behaviour.

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201702/t20170208_4742121.html

文章链接:http://www.nature.com/articles/ncomms14161?WT.feed_name=subjects_neuroscience

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