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Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis, Cell Research, publicated online,13 Jan.2017
2017-01-16 | 【     】【打印】【关闭

Cell Research, publicated online,13 Jan.2017,doi: 10.1038/cr.2017.8

Yongting Luo1,*, Hongxia Duan1,*, Yining Qian2,*, Liqun Feng2, Zhenzhen Wu1, Fei Wang1, Jing Feng1, Dongling Yang1, Zhihai Qin1 and Xiyun Yan1

Abstract

The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels the development of atherosclerosis. However, the mechanism that regulates the formation of macrophage foam cells and impedes their emigration out of inflamed plaques is still elusive. Here, we report that adhesion receptor CD146 controls the formation of macrophage foam cells and their retention within the plaque during atherosclerosis exacerbation. CD146 is expressed on the macrophages in human and mouse atheroma and can be upregulated by oxidized low-density lipoprotein (oxLDL). CD146 triggers macrophage activation by driving the internalization of scavenger receptor CD36 during lipid uptake. In response to oxLDL, macrophages show reduced migratory capacity toward chemokines CCL19 and CCL21; this capacity can be restored by blocking CD146. Genetic deletion of macrophagic CD146 or targeting of CD146 with an antibody result in much less complex plaques in high-fat diet-fed ApoE−/− mice by causing lipid-loaded macrophages to leave plaques. Collectively, our findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment.

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201701/t20170116_4737274.html

文章链接:http://www.nature.com/cr/journal/vaop/ncurrent/full/cr20178a.html

 

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