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  王晋辉 博士 研究员 博士生导师 

  国家“杰出青年基金”、中科院“百人计划”获得者

  中科院生物物理所,脑与认知科学国家重点实验室,创新课题组组长

  研究方向:

  1、记忆细胞工作原理

  2、精神疾病的神经环路机制

  3、神经细胞编程原理

  电子邮件(E-mail ) jhw@ibp.ac.cn ,电话(Tel) 010-64888472

  传真(Fax) 010-64871293,邮政编码 100101

  英文版个人网页

  简历 & 研究组工作摘要

  1992年  中国科学院上海生理研究所获博士学位

  1992-1994年  纽约州立大学博士后

  1994-1999年  美国德克萨斯大学医学中心神经生物系研究员

  1999.8-2004.5  美国堪萨斯大学生物系助理教授,博士生导师

  2003年12月至今 中科院“百人计划”海外杰出人才引进到生物物理研究所,任研究课题组长,研究员。获国家杰出青年科学基金资助,美国神经科学会会员

  研究方向:

  1) 记忆细胞工作原理:学习记忆是人类认知、逻辑思维和抉择的基础,记忆细胞的工作原理是有待澄清的神经科学问题。为了研究信息储存和记忆细胞工作原理,我们建立了感觉信息跨皮层储存的小鼠模型。感觉皮层神经元和神经胶质细胞重塑能够编码天然感觉信息和新的跨模式信息。这些联合记忆细胞在储存天然和新获得信息的同时也能通过不同的编程模式对其进行识别。这些联合记忆细胞是天生反射和新建反射的共同输出通路。联合记忆细胞的形成是基于相关皮层之间建立新轴突投射和新突触形成。某些microRNA在信息储存、联合记忆细胞以及新突触形成中起重要作用。这些研究在国际上首次阐述了哺乳动物的联合记忆细胞的自然属性。

  2) 精神疾病的神经环路机制:据WHO的估计全球约有3.5%的人群患有抑郁症和焦虑症,其发病与遗传易感和慢性应激有关。我们系统地建立了轻度不可预测的慢性应激导致小鼠抑郁的实验模型来研究抑郁症发病的细胞分子机理,包括不同类型神经元及其相互作用病理变化、边缘系统脑区间神经环路异常等。这些研究将为开发精神疾病防治新策略提供依据。

  3) 神经细胞编程原理:神经元相当于计算机的核心处理单元,但神经元编程模拟和数字信号。我们的研究聚焦在神经树突的模拟信号整合及其驱动胞体数字信号的产生,轴突放大和分流动作电位信号,轴突与其下游神经元编程能力的匹配,以及这些过程的可塑与稳态。这些研究将揭示神经网络和脑的编程原理,是模拟脑的神经计算机研发的基础。

  研究的技术手段:

  小鼠生理和病理行为分析,活体动物脑细胞离子信号的光学成像,活体动物脑细胞电信号记录分析,离体脑片神经元突触信号电生理记录分析,AAV追踪神经环路和突触形成,细胞内微量注射操纵细胞内生化反应和基因表达,以AAV为载体实现神经细胞内特异的基因过表达或敲除,免疫细胞化学方法分析蛋白表达,单细胞基因分析与神经元突触动力学相关的基因表达谱,以及数学物理方法探索神经元和突触编程规律。

  代表性论文(部分以唯一的第一或通讯作者发表的SCI收录期刊的研究论文)

  1) Jin-Hui Wang and De-Pei Feng (1992). Postsynaptic protein kinase C essential to both induction and maintenance of long-term potentiation in hippocampal CA1 region. Proc. Natl. Acad. Sci. USA, 89, 2576-2580.

  2) Jin-Hui Wang and Paul Kelly (1995). Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaM-KII and PKC activity. Neuron 15(2), 443-452.

  3) Jin-Hui Wang and Armin Stelzer (1996). Shared calcium signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendrites. Journal of Neurophysiology. 75 (4), 1687-1701.

  4) Jin-Hui Wang and Paul Kelly (1996), Regulation of synaptic facilitation by postsynaptic Ca2+ -CaM signaling pathway in rat hippocampal CA1 neurons. Journal of Neurophysiology. 76,276-286.

  5) Jin-Hui Wang and Paul Kelly (1996). The balance between postsynaptic Ca2+-dependent protein kinases and phosphates controlling synaptic strength. Learning & Memory 3, 170-181.

  6) Jin-Hui Wang and Paul Kelly (1997). Postsynaptic calcineurin activity down-regulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. Journal of Neuroscience. 17, 4600-4611.

  7) Jin-Hui Wang and Paul Kelly (1997). Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. Journal of Neurophysiology. 78, 2707-2716.

  8) Jin-Hui Wang* and Paul Kelly (2001). Ca2+/CaM signal pathway up-regulates glutamatergic synaptic function on non-pyramidal fast-spiking neurons in hippocampal CA1. Journal of Physiology (London) 533(2), 407-422.

  9) Mei Zhang, Fen-S Hung Yan Zhu, Zuoping Xie and Jin-Hui Wang* (2004). Calcium signal- dependent multigrade-plasticity of neuronal excitability developed postnatally. Journal of Neurobiology 61, 277-287.

  10) Jianning Wei, Mei Zhang, Yan Zhu and Jin-Hui Wang* (2004). Ca2+/CaM signal pathway up-regulates GABA synaptic function through cytoskeleton-mediated mechanisms. Neuroscience 127, 637-647.

  11) Na Chen, Xin Chen and Jin-Hui Wang* (2008). Homeostasis by coordination of subcellular compartment plasticity improves spike encoding. Journal of Cell Science, 121(17):2961-2971.

  12) Jin-Hui Wang*, J. Wei, X. Chen, J. Yu, N. Chen and J. Shi (2008). The gain and fidelity of transmission patterns at cortical excitatory unitary synapses improves spike encoding. Journal of Cell Science, 121(17):2951-2960.

  13) Hong Ni, Li Huang, Na Chen, Dongbo Liu, Fengyu Zhang, Ming Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2010). Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deprivation. PLoS One 5(10):e13736.

  14) Na Chen, Jiandong Yu, Hao Qian and Jin-Hui Wang* (2010). Axon amplifies somatic incomplete spikes to uniform. PLoS One 5(7):e11868.

  15) Rongjing Ge, Hao Qian and Jin-Hui Wang* (2011). Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons. Molecular Brain 4(19), 1~11.

  16) Jiandong Yu, Hao Qian, Na Chen and Jin-Hui Wang* (2011). Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PloS One 6(9): e25219.

  17) Jun Zhao, Dangui Wang and Jin-Hui Wang* (2012). Barrel cortical neurons and astrocytes coordinately respond to an increased whisker stimulus frequency. Molecular Brain 5,12.

  18) Fengyu Zhang, Bei Liu, Zhuofan Lei and Jin-Hui Wang* (2012). mGluR activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: Implication for anxiety-like behavior in DAB/2 mice. Molecular Bain 5(20), 1~12.

  19) Bing Ye, Li Huang, Zilong Gao, Ping Chen, Hong Ni, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2012). The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. PLoS One 7(8):e41986.

  20) Jiandong Yu, Hao Qian and Jin-Hui Wang* (2012). Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes. Molecular Brain 5(26):1~11.

  21) Guanjun Zhang, Zhilong Gao, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2013). Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs. Molecular Brain 6(2): 1~11.

  22) Zhilai Yang and Jin-Hui Wang* (2014). Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells. Molecular Brain 7(1):1-13.

  23) Rongjing Ge, Hao Qian, Na Chen and Jin-Hui Wang* (2014). Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons. Molecular Brain 7(26):1-16.

  24) Wei Lu, Bo Wen, Fengyu Zhang and Jin-Hui Wang* (2014). Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons. Molecular Brain 7(38):1-15.

  25) Bei Liu, Jing Feng and Jin-Hui Wang* (2014). Protein kinase C is essential for kainate-induced anxiety-like behavior and glutamatergic synapse upregulation in prefrontal cortex. CNS Neuroscience and Therapeutics 20:982-990.

  26) Bo Wen, Hao Qian, Jing Feng, Rong-Jing Ge, Xin Xu, Zhi-Qiang Cui, Ru-Yuan Zhu, Long-Sheng Pan, Zhi-Pei Ling and Jin-Hui Wang* (2015). A portion of inhibitory neurons in human TLE are functionally upregulated: an endogenous mechanism for seizure termination. CNS Neuroscience and Therapeutics 21:204-214.

  27) Dangui Wang, Jun Zhao, Zilong Gao, Na Chen, Bo Wen, Wei Lu, Zhuofan Lei, Changfeng Chen, Yahui Liu, Jing Feng and Jin-Hui Wang* (2015). Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals. Frontier in Cellular Neuroscience. 9:320, 1-17.

  28) Li Huang, Shidi Zhao, Wei Lu, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2015). Acidosis-induced dysfunction of cortical GABAergic neurons through astrocyte-related excitotoxicity. PLoS One. 10(10): e0140324.

  29) Zhuofan Lei, Bei Liu and Jin-Hui Wang* (2015). Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus. Hippocampus. DOI:10.1002/hipo.22540. Online.

  30) Aiping Xu, Shan Cui and Jin-Hui Wang* (2015). Incoordination among subcellular compartments is associated to depression-like behavior induced by chronic mild stress. International Journal of Neuropsychopharmacology. DOI:10.1093/ijnp/pyv122 Online.  

  

  资料来源:王晋辉研究员,2015-11-16网页更新

                 
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