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  刘志杰 博士 研究员 博士生导师 

  中科院“百人计划”获得者

  中科院生物物理所,生物大分子国家重点实验室,创新课题组组长(客座)

  研究方向:

  结构免疫学;感染与免疫蛋白质结构与功能;结构蛋白质组学新技术新方法

  电子邮件(E-mail ) liuzhj@shanghaitech.edu.cn

  电话(Tel) 010-64888426/021-20685008

  传真(Fax) 010-64888426

  邮政编码 100101

  课题组网站英文版个人网页

  简历 & 研究组工作摘要

  1991年-1995年 中国科学院生物物理研究所, 获博士学位

  1995年 University of Pittsburgh,博士后

  1995年-2005年 University of Georgia,博士后, 助理研究员,副研究员

  2006年- 中国科学院生物物理研究所,“百人计划”研究员

  2013年-今 上海科技大学,教授

  主要研究方向:

  天然免疫信号通路相关蛋白及其复合物的结构与功能研究;与人类肝脏疾病相关蛋白质的结构及基于结构的药物设计。结构蛋白质组学新技术和新方法的研究。

  研究生培养

  学生获奖情况

  华甜:2012年,研究生国家奖学金;

  华甜:2013年,研究生国家奖学金

  华甜:2012年,所论文奖(三等奖) 

  华甜:2013年,所论文奖(二等奖)              

  华甜:2013-2014学年, 三好学生  

  牛锋锋:2013年,博士研究生国家奖学金;

  牛锋锋:2013年,优秀博士研究生“保罗生物科技”特别奖;

  牛锋锋:2013年,生物物理研究所研究所所长论文奖二等奖;

  牛锋锋:2013年,第二届全国病毒学研究生论坛"一等奖;

  牛锋锋:2012年,中国科学院优秀学生奖;

  

  学生毕业去向信息

  1、Gaojie Song(宋高洁)  PhD student 2006-2009, Current: Harvard Medical School

  2、Yang Li (李杨)  PhD student 2004-2009, Current: Harvard Medical School

  3、Jie Yin (殷杰) PhD student 2005-2010, Current: UT Southwestern Medical Center

  4、Wenguang Liang (梁文光) PhD student 2006-2011, Current: University of Chicago

  5、Yangyan Zhou (周阳燕) PhD student 2007-2012, Current: Scripps Research Institute

  6、Heng Ru (茹衡)  PhD student 2007-2012, Current: Harvard Medical School

  7、Lianying Jiao(焦联营)PhD student 2007-2013, Current: UT Southwestern Medical Center

  8、Xiangmin Ni(倪向敏) PhD student 2008-2013, Current: 第三军医大学第二附属医院

  10、Elena Eremeeva  Visiting Scholar 2010.10-2011.2, Current: Institute of Biophysics, RAS

  

  组内成员学生信息:

  08级硕博:蒙冰、

  09级硕博:牛锋锋、李静

  10级硕博:姜艳、高小芹、

  11级硕博:华甜、

  12级硕博:曲露

  13级硕士:陈勇

  13级在职博士:彭瑶

  国际合作生:Pavel Natashin (Pasha)  Institute of  Biophysics, RAS, Russia

  代表性论文 (*Corresponding authors)

  1. X. Li, T. Hua, K. Vemuri, S. J. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, GW. Han, M. Iyer, R. Cinar, N. Coffey, J. Wang, M., Wu, V. Katritch, S. Zhao, G. Kunos, L. Bohn, A. Makriyannis, R Stevens. Liu ZJ* (2018) Crystal Structure of the Human Cannabinoid Receptor CB2. Cell, in press. 

  2. Y. Peng, J, McCorvy, K, Harpse, K Lansu, S Yuan, P Popov, L Qu, M Pu, T Che, L Nikolajsen, X Huang, Y Wu, L Shen, W E. Yoshimoto, K Ding, D Wacker, G Han, J Cheng, V Katritch, A A. Jensen, M. Hanson, S Zhao, D E. Gloriam, B L. Roth*, R C. Stevens*, Liu ZJ*, (2018) The Studies of 5-HT2C Receptor Reveal the Structural Basis of GPCR Polypharmacology. Cell, 172(4):719-730 

  3. T. Hua, K. Vemuri, S. Nikas, R. Laprairie, Y. Wu, L. Qu, M. Pu, A. Korde, S. Jiang, J.H. Ho, GW. Han, D. Ding, X. Li, H. Liu, S. M. Hanson, S. Zhao*, L. Bohn*, A. Makriyannis*, R Stevens. Liu ZJ* (2017) Crystal Structure of agonist-bound Human Cannabinoid Receptor CB1. Nature, 547 (7664): 468-471

  4. Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu Z.J*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 546(7657):312-315.

  5. T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn, A. Makriyannis, R Stevens. ZJ. Liu (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762.

  6. Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6:7300.

  7. J. Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang*, Liu ZJ*, W. Han*, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented "EF-Hand-Like" Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109.

  8. Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Research, 24(3):344-58.

  9. Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9.

  10. Ru, H., Ni, X. , Zhao, L. , Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu, Z. J*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Research, 23(6):855-8.

  11. OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu, Z. J*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086.

  12. Wu, D., Li, Y., Song, GJ, Zhang, R., Joachimiak, A., Shaw, N., & Liu, Z. J*. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, 69(18), 7294-301. (Cover)

  13. Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., Liu, Z. J*., Wang, B. C. & Rao, Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, 14(8), 779-84.

  14. Shaw, N., Cheng, C., and Liu ZJ*, (2007) Procedure for reductive methylation of protein to improve crystallizability. Nature Protocols DOI: 10.1038/nprot.2007.287

  特邀报告

  1. "The Structure of Aldehyde Dehydrogenase: Crystallographic Structure Determination and Description of the structure", Crystallography Seminar, Department of Biochemistry & Molecular Biology, University of Georgia, GA, Dec. 7, 1995,

  2. "Crystal Structure of Class 3 Aldehyde Dehydrogenase at 2.6? Resolution." Annual Meeting on Advances in Experimental Medicine and Biology, SD, July 8 (1996).

  3. "The Crystal Structure of class 3 Aldehyde Dehydrogenase: Don't Throw away that old X-100 Data", Siemens Area Detector Users Group meeting, Athens, GA, April 17-19, 1997

  4. "Refined Crystal Structure of Bacteriophage T7 RNA Polymerase", American Crystallographic Association Annual Meeting, DC, July 23 (1998).

  5. "Recent results using sulfur, selenium, and iron single wavelength anomalous scattering data in protein structure determination", ISAS Workshop 2000, University of Georgia, Athens, Georgia, April 18 (2000).

  6. "Recent results using sulfur, selenium, and iron single wavelength anomalous scattering data in protein structure determination", Middle Atlantic Crystallography Annual Meeting, West Virginia, May 5 (2000).

  7. "Crystal Structure of the Calcium-Regulated Photoprotein Obelin solved at 1.1? ", Tthe 11th international symposium on bioluminescence and chemiluminescence, Monterey, CA, Sept, 7 (2000).

  8. "Sulfur SAS Phasing: Theory and Practical Aspects" Pittsburgh Diffraction Conference, Pittsburg, PA, October 28, 2000.

  9. "Practical Aspects of Sulfur SAS Phasing: Case Studies I: S-SAD of Insulin (in-house data) S-SAD of Obelin (synchrotron data)", European Synchrotron Radiation Facility (ESRF) Workshop, Grenoble, France, June 24, 2001.

  10. "Practical Aspects of Sulfur ISAS Phasing", ISAS Workshop, ACA Annual Meeting, Los Angeles, CA, July 21, 2001.

  11. "Southeast Collaboratory for Structural Genomics: Current and Future", Beckman Chinese-American Scientific Symposium, Irvine, CA, Novber, 2002

  12. "Practical Aspects of Sulfur SAS Phasing", CCP4 Workshop, York, UK, January 2003

  13. "Crystal Structure Determination Using In-House Chromium X-Ray Source", American Crystallographic Association Annual Meeting, Cincinnati, July 23, 2003.

  14. "Crystal Salvaging Effort at SECSG", Protein Production and Crystallization Workshop, NIH, Bethesda, Md, March 29-31, 2004.

  15. "Practical Aspects of Sulfur SAS Phasing", 10th International Conference on the Crystallization of Biological Macromolecules, Beijing, China, June 5-8, 2004.

  16. "A Multi-Data-Set Data Collection Strategy Using Dose Derived Exposures for Optimum Data Acquisition", American Crystallographic Association Annual Meeting, Chicago, July 17-22, 2004.

  17. "Structural and Functional Analysis of Human p100 Protein", The 4th Congress of Biophysical Society of China, Qingdao, May, 2006.

  18. "Human Liver Structural Proteomics in China", The 4th International Conference on Structural Genomics, Beijing, Oct, 2006.

  19. "Structural and Functional Analysis of Human p100 Protein", The 9th International Biology and Synchrotron Radiation Conference, Manchester, Aug, 2007.

  20. "Bioinformatics-guided Target Selection in Human Liver Structural Proteomics Project", The Sixth International Conference on Bioinformatics, HK, Aug, 2007.

  21. "Structural Genomics and its Impact on Structural and Systems Biology in China", New Challenges in the Life Sciences: Prioritzing European Research in molecular System Biology, Florence, Oct, 2007.

  22. "(NZ)CH…O Contacts Assisted Crystallization", Asia Crystallography Associate Conference, Taipei, Nov, 2007.

  23. "Multifunctional transcriptional co-activator p100 is involved in splicing: functional and structural basis", The 6th TICPS International Conference, Shanghai, Nov. 5, 2007.

  24. "Crystal structure of coelenterazine-binding protein from Renilla muelleri at 1.72 ?", The 15th International Symposium on Bioluminescence & Chemiluminescence, Shanghai, May 13-17, 2008.

  25. "A Structural genomics approach in elucidating the Endo-?-N-acetylglycosaminidase A from Arthrobacter protophormiae", Uk-China and Chair Symposia, Liverpool, Sept. 25-26, 2008.

  26. "Methylation Assisted Crystallization of Protein Molecules", College of Sciences, Nankai University, March. 6, 2009.

  27. "Methylation Assisted Crystallization of Macromolecules", 6th Annual SER-CAT Symposium at the University of Alabama in Huntsville, March. 20, 2009.

  28. "Excitation coupling in bioluminescence: combined X-ray and NMR determination of the clytin-GFP topology", The 11th Congress of Biophysical Society of China, Guilin, China, July 15, 2009.

  29. "Data Collection and Structure Analysis", Cutting-edge methods and techniques in protein research: a workshop for scientists from developing countries, Beijing, China, July 16, 2009.

  30. "3D Structure of 5,10-Methenyltetrahydrofolate synthetase (MTHFS) and its application in anti-cancer drugs", The 199th Yang Scientist Symposium for drug target discovery, Nanjing, China, Sept. 12, 2009.

  31. "Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase (MTHFS) by N10-substituted folate analogues", China-Israel Binational Symposium: Theoretical and Experimental Approaches to Drug Design,Changzhou, China, Mar. 1, 2010.

  32. "Structural and Functional Analysis of Calcium Regulated Photoproteins", PhotoBiology & PhotoBiophysics Symposium,Guiyang, China, Aug. 9, 2010.

  33. "How Synchrotron Radiation Facility in Shanghai Aid the Structural Biology Research", The 160th Eastern Forum of Science & Technology,Shanghai, China, Sept. 16-17, 2010.

  34. "Introduction to Macromolecular Structures", EMBO Global Exchange Lecture Course: Structural and Biophysical Methods for Biological Macromolecules in Solution, Institute of High Energy Physics, China, April 28, 2011.

  35. "Recent practice on sulfur SAD phasing using soft X-rays", Workshop on Soft X-ray Crystallography,Chicago, US, May 4, 2011.

  36. "Structural basis of energy transfer in bioluminescent system of jellyfish Clytia and GFP complex", Nankai-UK Joint Meeting on Membrane Protein Structure and Function,Nankai University, China, May 11, 2011.

  37. "Protein-protein complexes in bioluminescence", The 17th International Biophysics Congress,Beijing, China, November 8, 2011.

  38. "The Evaluation of Sulfur’s Anomalous Signal in Diffraction Data and Beyond", 4th Winter School on Soft X-Rays in Macromolecular Crystallography,Grenoble, France, February 8, 2012.

  39. "Introduction to Macromolecular Structures", Siberian Federal University,Krasnoyarsk, Russia, March 1, 2012.

  40. "Protein Crystallography and its Applications", Siberian Federal University,Krasnoyarsk, Russia, March 2, 2012.

  41. "New Tools for S-SAD Phasing", ACA Annual Meeting, Boston, US, July 31, 2012.

  42. "Sulfur-SAD applications: data collection and phasing", International Workshop on New Developments of Methods and Software for Protein Crystallography, Xi’an, China, August 24, 2012.

  43. "Structural and functional analysis of the innate immune signaling adaptor protein STING and its potential for drug discovery", A Joint Meeting of the Asian Crystallographic Association (AsCA), Society of Crystallographers in Australia and New Zealand (SCANZ) and the BRAGG Symposium, Adelaide, AUS, Dec. 4, 2012.

  44. "Structural and functional analysis of viro infection and innate immune signaling and structure based drug discovery", Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Jan. 10, 2013.

  45. "Mission of iHuman Institute", 2013 Frontier of Global Bio-Phamaceutical Research, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), Shanghai, Sept. 24, 2013.

  46. "The influence of XFEL on structural biology of protein complex and membrane proteins", The 474 Xiangshan Scientific Symposium, Nanchang, Oct. 26-27, 2013.

  47. "Structural biology study on DNA sensors in innate immune signaling system", The Tenth Chinese Biophysical Society Congress, Nanchang, Oct. 28-31, 2013

  

  资料来源:刘志杰,2018-12-11更新 

                 
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