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  焦仁杰 博士 研究员 博士生导师 

  中科院生物物理所,脑与认知科学国家重点实验室,创新课题组组长

  研究方向:Mechanisms of cell proliferation and differentiation

  (细胞增殖与分化的机制)

  电子邮件(E-mail ) rjiao@ibp.ac.cn

  电话(Tel) 010-64867568

  传真(Fax) 010-64871293

  邮政编码 100101

  英文版个人网页 

  简历 & 研究组工作摘要

  焦仁杰研究员1965年1月30日生于江苏、泰兴。1987年毕业于北京大学生物学系细胞生物学及遗传学专业,获学士学位。1991年获北京大学细胞生物学硕士学位。同年留校任教。历任助教、讲师。1999年获苏黎世大学分子生物学研究所博士学位。2004年受聘于中国科学院生物物理研究所,任课题组长。2011年获中国科学院优秀导师称号。2017年受聘于广州医科大学,任课题组长、中法霍夫曼研究所所长。现任《Journal of Genetics and Genomics》副主编;英国癌症研究基金会(Cancer Research UK)、奥地利国家自然科学基金(Austrian National Science Foundation)等基金评审人;《Nature Communications》、《Journal of Cell Science》、《Journal of Molecular Cell Biology》等科技期刊论文评阅人。国家自然科学基金委二审专家。

  焦仁杰实验室主要研究方向是:细胞增殖与分化和细胞免疫调控的信号转导机制。他至今已在 Nature Cell Biol., Dev. Cell, Cell Res., Nat. Commun., Cancer Res., Development, Genetics, Mol. Cell. Biol., Mol. Biol. Cell, J. Cell Sci., Oncogene, J. Neurosci.等专业期刊上发表研究论文七十多篇。

  研究团队/课题组成员  

 

  梁雪红 

  高级实验师

  Email: liang@moon.ibp.ac.cn 

 

  伍洪刚

  博士生

  Email: whg9014@163.com

 

  朱南南

  博士生

  Email: nannanzhu88@hotmail.com

 

  郭雅文

  博士生

  Email: yawen_guo90@hotmail.com

  学生获奖

  宋延俊 2007 所长奖二等奖   

  杜贵平 2010 朱李月华奖  

  黄海 2011 院长奖特别奖   

  于忠胜 2013 国家奖学金  

  伍洪刚 2015 国家奖学金

  代表性论文(2010 - 2018)

  焦仁杰实验室近年发表论文(2010 - 2018):  

  1. Chen, J., N. Xu, C. Wang, P. Huang, H. Huang, Z. Jin, Z. Yu, T. Cai, R. Jiao and R. Xi.  2018.  Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.  Nature Cell Biol., 20(2): 152-161.

  2. H. WANG, Y. Yan, L. Min, L.-Y. ZHU, D.-Y. Zhang, R. Jiao*.  2017.  CRISPR/Cas9 System: an Important Tool for Brain and Cognitive Science.  Prog. Biochem. Biophys., 44(9): 799~805. [Perspectives]

  3. Yan, Y., H. Wang, M. Hu, L. Jiang, Y. Wang, P. Liu, X. Liang, J. Liu, C. Li, A. Lindström-Battle, W.-M. Deng and R. Jiao*.  2017.  HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.  Dev. Cell. 43: 99–111.

  4. Jiao, R.* and C. Gao*.  2017.  Anything impossible with CRISPR/Cas9?  Sci China: Life Sci., 60: 445-446. [Editorial review]

  5. Xie, G., H. Chen, D. Jia, Z. Shu, W. Palmer, X. Zeng, S. Hou, R. Jiao* and W.-M. Deng*, 2017. The SWI/SNF complex protein Snr1 is a tumor suppressor in Drosophila imaginal tissues. Cancer Res., 77: 862-873.

  6. Jiao, R.* and C. Gao*. 2016. The CRISPR/Cas9 genome editing revolution. J. Genet. Genomics, 43: 227-228. [Editorial review]

  7. Yan, Y., Y. Zhu, L. Liu and R. Jiao*. 2016. Transgenerational epigenetic inheritance of learning and memory: can flies tell us the truth? PiBB, 43: 337 – 347. [review]

  8. Peng, Q., Y. Wang, M. Li, D. Yuan, M. Xu, C. Li, Z. Gong, R. Jiao* and L. Liu*. 2016. cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function. J. Neurosci. 36: 4635 - 4646.

  9. Yan, Y. and R. Jiao*. 2016. HDAC6: A Molecule with Multiple Functions in Neurodegenerative Diseases. pp: 146-165. In “The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria”. Eds: V. K. Gribkoff, E. A. Jonas and J. M. Hardwick. John Wiley & Sons, Inc. [invited book chapter]

  10. Liu J., Y. Guo, C. Li, Y. Chen and R. Jiao* 2016. Methods for TALEN-Mediated Genomic Manipulations in Drosophila. Pp: 179-190. In “Methods in Molecular Biology” Series 1338 – Book: TALEN – Methods and Protocols. Eds: R. Kühn, W. Wurst and B. Wefers. Humana Press, Springer New York Heidelberg Dordrecht London. [invited book chapter]

  11. Su, F., Z. Huang, Y. Guo, R. Jiao, Z. Li, J. Chen, J. Liu. 2016. From random mutagenesis to precise genome editing: the development and evolution of genome editing techniques in Drosophila. Hereditas (Beijing), 38: 17―27.

  12. Zhu N., H. Wu, B. Yang, C. Li and R. Jiao*. 2015. F-Box Proteins: Multiple Functions Through One Platform. Gene Gene Edit., 1: 126-136. [invited review]

  13. Wu, H., Manu, R. Jiao and J. Ma. 2015. Temporal and spatial dynamics of scaling-specific features of a gene regulatory network. Nature Communications, 6: 10031.

  14. Yan Y., H. Wang, H. Chen, A. Lindström-Battle and R. Jiao*. 2015. Ecdysone and Insulin Signaling Play Essential Roles in Readjusting the Altered Body Size Caused by the dGPAT4 Mutation in Drosophila. J. Genet. Genomics, 42: 487-494.

  15. He, F.#, C. Wei#, H. Wu, D. Cheung, R. Jiao and J. Ma. 2015. Fundamental origins and limits for scaling a maternal morphogen gradient. Nature Communications, 6: 6679. DOI: 10.1038/ncomms7679

  16. Yu, Z., J. Liu, W.-M. Deng and R. Jiao*. 2015. Histone chaperone CAF-1: essential roles in multi-cellular organism development. Cell. Mol. Life Sci., 72(2): 327-337. [invited review]

  17. Zhang, H.#, C. Li#, H. Chen, H. Wu, W. Dui, F. Dai, W.-M. Deng* and R. Jiao*. 2015. SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Res., 25: 93-109.

  18. Xie, G., Z. Yu, D. Jia, R. Jiao* and W.-M. Deng*. 2014. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. J. Cell Sci., 127: 3830 – 3839.

  19. Liu, J., Y. Chen and R. Jiao*. 2014. TALEN-Mediated Drosophila Genome Editing: Protocols and Applications. Methods, 69: 22-31.

  20. Yu, Z.#, H. Chen#, J. Liu, H. Zhang, Y. Yan, N. Zhu, Y. Guo, B. Yang, Y. Chang, F. Dai, X. Liang, Y. Chen, Y. Shen, W.-M. Deng, J. Chen, B. Zhang, C. Li*, and R. Jiao*. 2014. Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome. Biol. Open, 3: 271-280.

  21. Yu, Z., M. Ren, Z. Wang, B. Zhang, Y.S. Rong, R. Jiao* and G. Gao*. 2013. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics, 195: 289-291.

  22. Yu, Z., H. Wu, H. Chen, R. Wang, X. Liang, J. Liu, C. Li, W.-M. Deng* and R. Jiao*. 2013. CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development. Development, 140: 3635-3644.

  23. Dui, W., B. Wei, F. He, W. Lu, C. Li, X. Liang, J. Ma* and R. Jiao*. 2013. The Drosophila F-box protein dSkp2 regulates cell proliferation through targeting Dacapo for degradation. Mol. Biol. Cell., 24: 1676-1687.

  24. Wei, C., J. Liu, Z. Yu, B. Zhang*, G. Gao* and R. Jiao*. 2013. TALEN or Cas9 -- rapid, efficient and specific choices for genomic modifications. J. Genet. Genomics, 40: 281-289.

  25. Zhang, Q., J. Wu, R. Wu, J. Ma, G. Du, R. Jiao, Y. Tian, Z. Zheng, Z. Yuan. 2012. DJ-1 Promotes the Proteasomal Degradation of Fis1: Implication of DJ-1 in the Neuronal Protection. Biochem. J., 447: 261-269.

  26. Zhou, C., H. Huang, S. Kim, H. Lin, X. Meng, K.-A. Han, A.-S. Chiang, J. W. Wang, R. Jiao, and Y. Rao. 2012. Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J. Neurosci., 32: 14281–14287.

  27. Wu, Q., J. Liu, Y. Chen and R. Jiao*. 2012. dCAF-1-p55 is essential for Drosophila development and involved in the maintenance of chromosomal stability. Prog. Biochem. Biophys., 39: 1073-1081.

  28. Dui, W., W. Lu, J. Ma* and R. Jiao*. 2012. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. J. Genet. Genomics, 39: 397-413.

  29. Xie, G., H. Zhang, G. Du, Q. Huang, X. Liang, J. Ma* and R. Jiao*. 2012. Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. PLoS One, 7: e36362.

  30. Liu, J., C. Li, Z, Yu, P. Huang, H. Wu, C. Wei, N. Zhu, Y. Shen, Y. Chen, B. Zhang, W.-M. Deng* and R. Jiao*. 2012. Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy. J Genet Genomics, 39: 209-215.

  31. Huang, H. and R. Jiao*. 2012. The roles of chromatin assembly factor 1 in the epigenetic control of chromatin plasticity. Sci. China Life Sci., 55: 15-19. [invited review]

  32. Huang, H., N. Zhu and R. Jiao*. 2011. The sumoylation pathway modulates JNK signaling in Drosophila. Prog. Biochem. Biophys., 38: 568-574. [Scientific News and Perspectives]

  33. Liu, J., Q. Wu, D. H, T. Ma, L. Du, W. Dui, X. Guo and R. Jiao*. 2011. Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. J. Genet. Genomics, 38: 225-234.

  34. Huang, H., G. Du, H. Chen, X. Liang, C. Li, N. Zhu, L. Xue, J. Ma and R. Jiao*. 2011. Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development, 138: 2477-2485.

  35. Du, G. and R. Jiao*. 2011. To prevent neurodegeneration: HDAC6 uses different strategies for different challenges. Commun. Integr. Biol., 4: 139-142. [Invited review]

  36. Huang, H., Z. Yu, S. Zhang, X. Liang, J. Chen, C. Li, J. Ma and R. Jiao*. 2010. Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. J. Cell Sci., 123: 2853-2861.

  37. Yu, Z. and R. Jiao*. 2010. Advances in Drosophila gene targeting and related techniques. Front. Biol., 5(3): 238-245. [Invited review]

  38. Chen, Y., W. Dui, Z. Yu, C. Li, J. Ma and R. Jiao*. 2010. Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo. Protein & Cell. 1(5): 478-490.

  39. Du, G., X. Liu, X. Chen, M. Song, Y. Yan, R. Jiao* and C.-C. Wang*. 2010. Drosophila histone deacetylase 6 protects dopaminergic neurons against α-synuclein toxicity by promoting inclusion formation. Mol. Biol. Cell. 21: 2128-2137.

  40. He, F., Y. Wen, D. Cheung, J. Deng, L.J. Lu, R. Jiao* and J. Ma*. 2010. Distance measurements via the Bicoid morphogen gradient in Drosophila embryos. BMC Dev. Biol., 10: 80-93.

  41. He, F., T. Saunders, Y. Wen, D. Cheung, R. Jiao, P. Rein ten Wolde, M. Howard, and J. Ma. 2010. Shaping a morphogen gradient for positional precision. Biophys. J. 99: 97-107.

  教材编著:

  1、陈毅序、焦仁杰。2011年10月。染色质可塑性与基因组稳定性(第四章)。《分子细胞生物学》(第二版)主编:陈晔光、张传茂、陈佺。清华大学出版社。北京  

  2、焦仁杰。2011年6月。细胞核与染色质(第十一章)。《细胞生物学》(第四版)主编:翟中和、王喜中、丁明孝。高等教育出版社。北京。

  教材翻译:

  1、谢更强、焦仁杰。2011年3月。精编干细胞生物学研究方法。pp408-483。科学出版社。北京。

  2、焦仁杰。2009年1月。精编干细胞生物学。pp56-70 and 90-105。科学出版社。北京。

 

  资料来源:焦仁杰研究员,2018-04-26网页更新

                 
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