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  高光侠 博士 研究员 博士生导师 

  国家“杰出青年基金”、人事部“百千万人才计划”、中科院“百人计划”获得者

  中科院感染与免疫重点实验室主任,创新课题组组长  

  研究方向:逆转录病毒与宿主作用的分子机制

  电子邮件(E-mail ) gaogx@moon.ibp.ac.cn 

  电话(Tel) 010-64888545

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  邮政编码 100101

  英文版个人网页

  课题组网站

  简历 & 研究组工作摘要

  1988 毕业于北京大学生物系生物化学专业,获理学士学位 

  1995 毕业于美国哥伦比亚大学生化系,获博士学位 

  1995-1999 美国哥伦比亚大学生化系,Howard Hughes Medical Institute 博士后 

  1999-2001 美国哥伦比亚大学生化系,Associate Research Scientist 

  2001年至今 中国科学院百人计划研究员引进回国。现为《中国病毒学》和《病毒学报》编委,BMC MicrobiologyAssociate Editor 

  HIV引起的艾滋病严重威胁人类健康,对HIV复制机理的了解是开发有效治疗策略的前提和基础。与病毒长期共存过程中,宿主进化产生了多种机制限制病毒的复制;HIV病毒相应地也进化出多种应对宿主排斥的机制。宿主与病毒相互作用过程是一个精彩的博弈过程,对其作用机理的了解不仅有助于开发新的治疗策略,也已经并将继续揭示诸多具有普遍意义的生物学规律。本课题组在前期的工作中,利用高通量功能基因组筛选系统克隆了宿主抗病毒蛋白ZAP,并对其作用机理开展了深入研究,发现ZAP能够特异性结合病毒mRNA,抑制其翻译起始并招募细胞内mRNA降解机器降解病毒RNA,从而抑制HIV等病毒的复制。近期的研究工作主要是鉴定新的宿主抗病毒因子。目前已经获得近10个具有抗HIV功能的宿主因子,正在分析其作用机制。代表性成果发表在《Science》、《EMBO J》、《Nat Struct Mol Biol》、《Proc Natl Acad Sci USA》等国际学术期刊。 

  代表性论文

  1. Tang Q, Wang X, Gao G*. (2016) ZAPS inhibits influenza A viral protein expression and is antagonized by the virus encoded NS1. J Virol. Nov 2. pii: JVI.01909-16.

  2. Wang X, Li M, Zhao J, Li S, MacDonald M, Rice C, Gao X, Gao G*. (2016) Sindbis virus can exploit a host antiviral protein to evade immune surveillance. J Virol 90(22): p10247-10258.

  3. Wang Q, Zhang X, Han Y, Wang X*, Gao G*. (2016) M2BP inhibits HIV-1 virion production in a vimentin filamentsdependent manner. Scientific Reports. Sep 8;6:32736.

  4. Tao X, Gao G*. (2015) Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs. Mol Cell Biol. Nov 15;35(22):3921-32.

  5. Mu X, Fu Y, Zhu Y, Wang X, Xuan Y, Shang H, Goff SP, Gao G*. (2015) HIV-1 exploits RuvB-like 2 to balance viral protein expression. Cell Host & Microbe. Aug 12;18(2):233-42.

  6. Mu X, Li W, Wang X, Gao G*. (2013) YB-1 stabilizes HIV-1 genomic RNA and enhances viral production. Protein & Cell. Aug;4 (8):591-7

  7. Xuan Y, Gong D, Qi J, Han C, Deng H, Gao G*. (2013) ZAP inhibits murine gammaherpesvirus-68 ORF64 expression and is antagonized by RTA, J Virol. 87 (5): 2735-43.

  8. Zhu Y, Wang X, Goff SP, Gao G*. (2012) Translational repression precedes and is required for ZAP-mediated mRNA decay. EMBO J. 31 (21):4236-46.

  9. Li W, Wang X, Gao G*. (2012) Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA. Protein & Cell. Dec;3(12):943-9.

  10. Xuan Y, Liu L, Shen S, Deng H, Gao G*. (2012) Zinc-finger antiviral protein inhibits murine gammaherpesvirus-68 M2 expression and regulates viral latency in cultured cells. J Virol. 86 (22):12431-4.

  11. Wang, X., Tu, F., Zhu, Y., and Gao G*. (2012) Zinc-finger antiviral protein inhibits XMRV infection. PLoS One 7, e39159

  12. Sun L, Lv F, Guo X, Gao G*. (2012) Glycogen synthase kinase 3β (GSK3β) modulates antiviral activity of zinc-finger antiviral protein (ZAP). J Biol Chem. 287 (27): 22882-8.

  13. Chen S, Xu Y, Zhang K, Wang X, Sun J, Gao G*, Liu Y*. (2012) Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. Nat Struct Mol Biol. 19 (4): 430-5.

  14. Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, Sun J, Wu L, Zheng Y, Gao G*. (2011) Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci USA. Sep 20;108 (38):15834-9.

  15. Ding J, Su L, Gao G*. (2011) Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain. Protein & Cell. Jun;2 (6):470-6.

  16. Mai Y, Gao G*. (2010) Expression of IMP1 Enhances Production of Murine Leukemia Virus Vector by Facilitating Viral Genomic RNA Packaging. PLoS ONE. Dec 29; 5 (12):e15881.

  17. Ye P, Liu S, Zhu Y, Chen G, Gao G*. (2010) DEXH-Box Protein DHX30 is required for optimal function of the zinc-finger antiviral protein. Protein & Cell. Vol.1 (10),956-964.

  18. Huang Z, Wang X, Gao G*. (2010) Analyses of SELEX-derived ZAP-binding RNA aptamers suggest that the binding specificity is determined by both structure and sequence of the RNA. Protein & Cell. Vol.1(8), 752-759.

  19. Wang X†, Lv F†, Gao G*. (2010) Mutagenesis analysis of the zinc-finger antiviral protein. Retrovirology. Mar 13;7:19.

  20. Xu J, Liu S, Xu Y, Tian B, Gao G*. (2009) Identification of the nonstructural protein 4B of hepatitis C virus as a factor that inhibits the antiviral activity of interferon-alpha. Virus Research. 141(1): 55–62.

  21. Zhu Y, Gao G*. (2008) ZAP-mediated mRNA degradation.  RNA Biology 5 (2): 65-7 (Invited minireview)

  22. Chen G, Guo X, Lv F, Gao G*. (2008) p72 DEAD box RNA helicase is required for optimal function of the Zinc-finger antiviral protein. Proc Natl Acad Sci USA. 105 (11): 4352-7.

  23. Guo X., Ma J., Sun J., and Gao G*. (2007) The Zinc-finger Antiviral Protein Recruits the RNA Processing Exosome to Degrade Target RNAs. Proc Natl Acad Sci USA. Vol. 104 (1): 151-6

  24. Duan J, Ji X, et al, Gao G*, Yan X* (2006) A human neutralizing antibody against a conformational epitope shared by oligomeric S1 protein. Antiviral Therapy 11(1): 117-23

  25. Liu S, Goff SP and Gao G* (2006) Gln84 of Moloney murine leukemia virus reverse transcriptase regulates the incorporation rates of ribonucleotides and deoxyribonucleotides. FEBS Letters 580: 1497-1501.

  26. Guo X, Carroll JW, Macdonald MR, Goff SP, Gao G*. (2004) The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifs. J Virol. Dec;78(23):12781-7.

  27. Liu L, Chen G, Ji X, Gao G* (2004). ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein. Biochem Biophys Res Commun. Aug 27;321(3):517-23.

  28. Gao G, Goff SP (2004) Isolation of suppressor genes that restore retrovirus susceptibility to a virus-resistant cell line. Retrovirology. Sep 28;1 (1):30.

  29. Gao, G.,Guo,X and Goff, S.P. (2002). Inhibition of Retroviral RNA Production by ZAP, a CCCH-type Antiviral Protein. Science 297:1703-1706.

  30. 王俊,王延轶,王盛典,田志刚,刘利新,刘昱,杨艳,李姝,李颖,陈宇,陈永艳,陈桂芳,郑世军,钟波,郭德银,高光侠,康曦,舒红兵,抗病毒天然免疫(内源性免疫:宿主限制因子),科学出版社,39万字,2009

  

  资料来源:高光侠研究员,2017-02-07网页更新

                 
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